Month: December 2022

Identification of a Novel 1,4,8-Triazaphenanthrene Derivative as a Neuroprotectant for Dopamine Neurons Vulnerable in Parkinson’s Disease was written by Le Douaron, Gael;Ferrie, Laurent;Sepulveda-Diaz, Julia E.;Seon-Meniel, Blandine;Raisman-Vozari, Rita;Michel, Patrick P.;Figadere, Bruno. And the article was included in ACS Chemical Neuroscience in 2017.Related Products of 166402-16-0 This article mentions the following:

Parkinson’s disease is a chronic degenerative disease characterized by motor symptoms, which result from the death of midbrain dopamine neurons and concomitant disruption of dopamine mediated neurotransmission. No curative treatment is currently available for this disorder in clin. practice. In the search for druggable neuroprotective compounds for dopamine neurons, the authors have synthesized new 1,4,8-triazaphenanthrenes by combination of 6-endo-dig-cycloisomerization of propargylquinoxalines and Suzuki or Sonogashira cross-coupling reaction. Neuroprotection assessment of newly synthesized 1,4,8-triazaphenanthrenes in a Parkinson’s disease cellular model has led to the selection of hit compound I. In vitro characterization of I showed that this compound operates via a direct effect on DA neurons with no impact on astroglial cells. Most interestingly, I was able to counteract neurodegeneration in a MPTP lesioned mouse model of Parkinson’s disease, making this compound a promising drug candidate for the treatment of this disorder. In the experiment, the researchers used many compounds, for example, 3-Chloroquinoxalin-6-amine (cas: 166402-16-0Related Products of 166402-16-0).

3-Chloroquinoxalin-6-amine (cas: 166402-16-0) belongs to quinoxaline derivatives. Quinoxaline is isomeric with other naphthyridines including quinazoline, phthalazine and cinnoline. Quinoxalines are used in the treatment of bacterial, cancer, and HIV infections. Moreover, varenicline, a clinical drug is used for treating nicotine addiction, also contains quinoxaline moiety.Related Products of 166402-16-0

Referemce:
Quinoxaline – Wikipedia,
Quinoxaline | C8H6N2 | ChemSpider

CuI/Oxalamide Catalyzed Couplings of (Hetero)aryl Chlorides and Phenols for Diaryl Ether Formation was written by Fan, Mengyang;Zhou, Wei;Jiang, Yongwen;Ma, Dawei. And the article was included in Angewandte Chemie, International Edition in 2016.Quality Control of 6-Chloroquinoxaline This article mentions the following:

Couplings between (hetero)aryl chlorides and phenols can be effectively promoted by CuI in combination with an N-aryl-N’-alkyl-substituted oxalamide ligand to proceed smoothly at 120 °C. For this process, N-aryl-N’-alkyl-substituted oxalamides are more effective ligands than bis(N-aryl)-substituted oxalamides. A wide range of electron-rich and electron-poor aryl and heteroaryl chlorides gave the corresponding coupling products in good yields. Satisfactory conversions were achieved with electron-rich phenols as well as a limited range of electron-poor phenols. Catalyst and ligand loadings as low as 1.5 mol % are sufficient for the scaled-up variants of some of these reactions. Thus, e.g., coupling of 4-chlorotoluene with phenol in presence of CuI and oxalamide I afforded 4-methylphenyl Ph ether (96%). In the experiment, the researchers used many compounds, for example, 6-Chloroquinoxaline (cas: 5448-43-1Quality Control of 6-Chloroquinoxaline).

6-Chloroquinoxaline (cas: 5448-43-1) belongs to quinoxaline derivatives. Quinoxalines are important class of heterocyclic compounds, associated with wider pharmacological applications. Quinoxalines are used in the treatment of bacterial, cancer, and HIV infections. Moreover, varenicline, a clinical drug is used for treating nicotine addiction, also contains quinoxaline moiety.Quality Control of 6-Chloroquinoxaline

Referemce:
Quinoxaline – Wikipedia,
Quinoxaline | C8H6N2 | ChemSpider

Synthesis and application of novel styryl dyes derived from 1,4-diethyl-1,2,3,4-tetrahydro-6-methoxyquinoxaline was written by Satam, Vijay;Rajule, Rajkumar;Bendre, Samir;Bineesh, Purushotthaman;Kanetkar, Vinod. And the article was included in Journal of Heterocyclic Chemistry in 2009.Category: quinoxaline This article mentions the following:

1,4-Diethyl-1,2,3,4-tetrahydro-7-methoxyquinoxaline-6-carboxaldehyde was synthesized, characterized, and condensed with suitably substituted active methylene compounds by classical Knoevenagel condensation to obtain five monostyryl dyes and a bis-styryl dye. These novel styryl dyes have hues varying from orange to violet. The dyes were applied to polyester fibers. The spectral and thermal characteristics of the dyes and fastness properties of the dyed polyester fabric were investigated. In the experiment, the researchers used many compounds, for example, 6-Methoxyquinoxaline (cas: 6639-82-3Category: quinoxaline).

6-Methoxyquinoxaline (cas: 6639-82-3) belongs to quinoxaline derivatives. Quinoxaline derivatives are important constituents of pharmacologically active compounds, including as well as for RNA synthesis inhibition, reactive dyes and pigments, azo dyes, flurox Cylin Dyes, Corrosion Inhibitors and Photovoltaic Polymers. Quinoxaline and its analogues may also be formed by reduction of amino acids substituted 1,5-difluoro-2,4-dinitrobenzene (DFDNB),One study used 2-iodoxybenzoic acid (IBX) as a catalyst in the reaction of benzil with 1,2-diaminobenzene.Category: quinoxaline

Referemce:
Quinoxaline – Wikipedia,
Quinoxaline | C8H6N2 | ChemSpider

Development of an Air-Stable Nickel Precatalyst for the Amination of Aryl Chlorides, Sulfamates, Mesylates, and Triflates was written by Park, Nathaniel H.;Teverovskiy, Georgiy;Buchwald, Stephen L.. And the article was included in Organic Letters in 2014.Computed Properties of C8H5ClN2 This article mentions the following:

A new air-stable nickel precatalyst for C-N cross-coupling is reported. The developed catalyst system displays a greatly improved substrate scope for C-N bond formation to include both a wide range of aryl and heteroaryl electrophiles and aryl, heteroaryl, and alkylamines. The catalyst system is also compatible with a weak base, allowing the amination of substrates containing base-sensitive functional groups. In the experiment, the researchers used many compounds, for example, 6-Chloroquinoxaline (cas: 5448-43-1Computed Properties of C8H5ClN2).

6-Chloroquinoxaline (cas: 5448-43-1) belongs to quinoxaline derivatives. Condensed heterocycles of quinoxalines have become attractive targets in synthetic and medicinal chemistry due to their significant biological activities. Quinoxalines are used in the treatment of bacterial, cancer, and HIV infections. Moreover, varenicline, a clinical drug is used for treating nicotine addiction, also contains quinoxaline moiety.Computed Properties of C8H5ClN2

Referemce:
Quinoxaline – Wikipedia,
Quinoxaline | C8H6N2 | ChemSpider

Quinoxaline chemistry. Part 12. 3-Carboxy-2-phenoxy-6(7)-substituted quinoxalines and N-[4-[6(7)-substituted-3-carboxyquinoxalin-2-yl]hydroxy]benzoylglutamates. Synthesis and evaluation of in vitro anticancer activity was written by Vitale, Gabriella;Corona, Paola;Loriga, Mario;Paglietti, Giuseppe. And the article was included in Farmaco in 1998.SDS of cas: 49679-45-0 This article mentions the following:

Thirty quinoxalines I, bearing a substituted phenoxy or oxybenzoylglutamate group on position 2, a carbethoxy or carboxy group on position 3, and a trifluoromethyl group on position 6 or 7 of the heterocycle, were prepared in order to evaluate their in vitro anticancer activity. Screening of over 21 compounds showed that only a few derivatives exhibited a moderate growth inhibition activity on various tumor panel cell lines at a 10^-4 molar concentration The acid derivatives showed no growth inhibition activity. The results obtained in this series indicate that, in general, carboxy or carbethoxy groups close to the O-link with Ph or benzoyl glutamates on position 2 are detrimental for anticancer activity. In the experiment, the researchers used many compounds, for example, Ethyl 3-chloroquinoxaline-2-carboxylate (cas: 49679-45-0SDS of cas: 49679-45-0).

Ethyl 3-chloroquinoxaline-2-carboxylate (cas: 49679-45-0) belongs to quinoxaline derivatives. Quinoxalines have received a significant amount of attention due to their potential use in fighting various pathophysiological conditions like epilepsy, Parkinson’s, and Alzheimer’s diseases. The parent substance of the group, quinoxaline, results when glyoxal is condensed with 1,2-diaminobenzene. Substituted derivatives arise when α-ketonic acids, α-chlorketones, α-aldehyde alcohols and α-ketone alcohols are used in place of diketones.SDS of cas: 49679-45-0

Referemce:
Quinoxaline – Wikipedia,
Quinoxaline | C8H6N2 | ChemSpider