Aqueous Hydrofluoric Acid Catalyzed Facile Synthesis of 2,3,6-Substituted Quinoxalines was written by Chandra Shekhar, A.;Ravi Kumar, A.;Sathaiah, G.;Raju, K.;Srinivas, P. V. S. S.;Shanthan Rao, P.;Narsaiah, B.. And the article was included in Journal of Heterocyclic Chemistry in 2014.Safety of 6-Chloroquinoxaline This article mentions the following:
A versatile synthetic route for the preparation of 2,3,6-trisubstituted quinoxalines I (R = H, NO2, Cl, COPh, R1 = H, Me, Ph, 4-FC6H4, 4-F3CC6H4) in excellent yield is developed from o-diamines and 1,2-dicarbonyl compounds in which aqueous hydrofluoric acid was employed as the medium and catalyst. Other salient features of this protocol include milder conditions, absence of coupling agents, and easy workup procedures. In the experiment, the researchers used many compounds, for example, 6-Chloroquinoxaline (cas: 5448-43-1Safety of 6-Chloroquinoxaline).
6-Chloroquinoxaline (cas: 5448-43-1) belongs to quinoxaline derivatives. Quinoxalines are important class of heterocyclic compounds, associated with wider pharmacological applications. The antitumoral properties of quinoxaline compounds have been of interest. Recently, quinoxaline and its analogs have been investigated as the catalyst’s ligands.Safety of 6-Chloroquinoxaline
Referemce:
Quinoxaline – Wikipedia,
Quinoxaline | C8H6N2 | ChemSpider