Nickel-Catalyzed Amination of Aryl Chlorides with Ammonia or Ammonium Salts was written by Green, Rebecca A.;Hartwig, John F.. And the article was included in Angewandte Chemie, International Edition in 2015.Reference of 5448-43-1 This article mentions the following:
The nickel-catalyzed amination of aryl chlorides to form primary arylamines with ammonia or ammonium sulfate and a well-defined single-component nickel(0) pre-catalyst, containing a Josiphos ligand and an η2-bound benzonitrile ligand, was reported. This system also catalyzed the coupling of aryl chlorides with gaseous amines in the form of their hydrochloride salts. In the experiment, the researchers used many compounds, for example, 6-Chloroquinoxaline (cas: 5448-43-1Reference of 5448-43-1).
6-Chloroquinoxaline (cas: 5448-43-1) belongs to quinoxaline derivatives. Condensed heterocycles of quinoxalines have become attractive targets in synthetic and medicinal chemistry due to their significant biological activities. Quinoxaline-1,4-di-N-oxide derivatives have shown to improve the biological results and are endowed with anti-viral, anti-cancer, anti-bacterial, and anti-protozoal activities with application in many other therapeutic areas.Reference of 5448-43-1
Referemce:
Quinoxaline – Wikipedia,
Quinoxaline | C8H6N2 | ChemSpider