Nickel/Photoredox-Catalyzed Methylation of (Hetero)aryl Chlorides Using Trimethyl Orthoformate as a Methyl Radical Source was written by Kariofillis, Stavros K.;Shields, Benjamin J.;Tekle-Smith, Makeda A.;Zacuto, Michael J.;Doyle, Abigail G.. And the article was included in Journal of the American Chemical Society in 2020.Name: 6-Chloroquinoxaline This article mentions the following:
A radical approach for the methylation of (hetero)aryl chlorides R-Cl (R = 4-CNC6H4, 2-CF3C6H4, 9-oxo-thioxanthen-2-yl, 4-(6-methylpyridin-2-yl)phenyl, 4-phenythiazol-2-yl, etc.) using nickel/photoredox catalysis wherein tri-Me orthoformate, a common laboratory solvent, serves as a Me source has been described. This method permits methylation of (hetero)aryl chlorides and acyl chlorides R1C(O)Cl (R1 = (CH2)10-CH3, adamantan-1-yl, C6H5O, N,N-diphenylamino, etc.) at an early and late stage with broad functional group compatibility. Mechanistic investigations indicate that tri-Me orthoformate serves as a source of Me radical via β-scission from a tertiary radical generated upon chlorine-mediated hydrogen atom transfer. In the experiment, the researchers used many compounds, for example, 6-Chloroquinoxaline (cas: 5448-43-1Name: 6-Chloroquinoxaline).
6-Chloroquinoxaline (cas: 5448-43-1) belongs to quinoxaline derivatives. Quinoxalines have received a significant amount of attention due to their potential use in fighting various pathophysiological conditions like epilepsy, Parkinson’s, and Alzheimer’s diseases. Quinoxaline-1,4-di-N-oxide derivatives have shown to improve the biological results and are endowed with anti-viral, anti-cancer, anti-bacterial, and anti-protozoal activities with application in many other therapeutic areas.Name: 6-Chloroquinoxaline
Referemce:
Quinoxaline – Wikipedia,
Quinoxaline | C8H6N2 | ChemSpider