Ni-nanoparticles: An efficient catalyst for the synthesis of quinoxalines was written by Kumar, Ajeet;Kumar, Santosh;Saxena, Amit;De, Arnab;Mozumdar, Subho. And the article was included in Catalysis Communications in 2008.Product Details of 5448-43-1 This article mentions the following:
Biol. active quinoxalines were efficiently synthesized in excellent yields and in less reaction time using inexpensive, monodispersed and easily recyclable Ni-nanoparticles. In order to elucidate the role of the Ni-nanoparticles, a control reaction was conducted using glyoxal and o-phenylenediamine in acetonitrile in the absence of Ni-nanoparticles. Quinoxaline was formed in around 10 h with a 30% yield. However, the same reaction carried out in acetonitrile using 10 mol.% of Ni-nanoparticles (14-18 nm) at 25° and stirred under N2 gave quinoxaline in quant. yield in 10 min. The separation of the product was facile and the catalyst could be separated and recycled by mild centrifugation. This method is very quick, avoids the use of expensive reagents, high temperatures (the reaction takes place at room temperature) and leads to excellent yield. In the experiment, the researchers used many compounds, for example, 6-Chloroquinoxaline (cas: 5448-43-1Product Details of 5448-43-1).
6-Chloroquinoxaline (cas: 5448-43-1) belongs to quinoxaline derivatives. Quinoxalines have received a significant amount of attention due to their potential use in fighting various pathophysiological conditions like epilepsy, Parkinson’s, and Alzheimer’s diseases. Quinoxalines are used in the treatment of bacterial, cancer, and HIV infections. Moreover, varenicline, a clinical drug is used for treating nicotine addiction, also contains quinoxaline moiety.Product Details of 5448-43-1
Referemce:
Quinoxaline – Wikipedia,
Quinoxaline | C8H6N2 | ChemSpider