A near-infrared fluorescent probe with an improved Stokes shift achieved by tuning the donor-acceptor-donor character of the rhodamine skeleton and its applications was written by Gong, Jin;Liu, Chang;Jiao, Xiaojie;He, Song;Zhao, Liancheng;Zeng, Xianshun. And the article was included in RSC Advances in 2020.COA of Formula: C9H8N2O This article mentions the following:
In this paper, we report a novel near-IR (NIR) mitochondrion-targeted fluorescent probe, RQS, with an improved Stokes shift (96 nm) for the specific detection of mitochondrial mercury ion (Hg2+) because mitochondrion is one of the main targeted organelles of Hg2+. For the preparation of the probe, a novel asym. fluorescent xanthene dye RQ was first synthesized by tuning the donor-acceptor-donor (D-A-D) character of the rhodamine skeleton, and then the probe RQS was constructed by the mechanism of mercury-promoted ring-opening reaction. As expected, RQS could be used for the specific detection of Hg2+ with high selectivity, high sensitivity, and a detection limit down to the nanomolar range (2 nM). Importantly, RQS is capable of specifically distributing in mitochondria, and thus detect Hg2+ in real-time and provided a potential tool for studying the cytotoxic mechanisms of Hg2+. In the experiment, the researchers used many compounds, for example, 6-Methoxyquinoxaline (cas: 6639-82-3COA of Formula: C9H8N2O).
6-Methoxyquinoxaline (cas: 6639-82-3) belongs to quinoxaline derivatives. Condensed heterocycles of quinoxalines have become attractive targets in synthetic and medicinal chemistry due to their significant biological activities. The antitumoral properties of quinoxaline compounds have been of interest. Recently, quinoxaline and its analogs have been investigated as the catalyst’s ligands.COA of Formula: C9H8N2O
Referemce:
Quinoxaline – Wikipedia,
Quinoxaline | C8H6N2 | ChemSpider