An efficient synthesis and biological activity of quinoxaline-2-carboxylic acid and its derivatives was written by Kumar, Navneet;Sharma, Pratima;Kaur, Navjeet;Pareek, Aastha. And the article was included in Journal of Applicable Chemistry (Lumami, India) in 2013.Reference of 49679-45-0 This article mentions the following:
Condensation of ortho phenyldiamine with acetic acid and form 2-tetrahydroxy Bu quinoxaline which further react with hydrogen peroxide and solid sodium hydroxide form quinoxaline-2-carboxylic acid. Ethyl-3-hydroxyquinoxaline-2-carboxylate reacts with POCl3 and to form ethyl-3-chloroquinoxaline-2-carboxylate. Ethyl-3-chloroquinoxaline-2-carboxylate reacts with sodium hydroxide, alc., sodium methoxide and form 3-ethoxyquinoxaline-2-carboxylic acid, 3-amino quinoxaline-2-carboxylic acid, 3-methoxy quinoxaline-2-carboxylic acid, with good yield. The structure of the compounds was established on the basis of IR, and 1H NMR, spectral data. In the experiment, the researchers used many compounds, for example, Ethyl 3-chloroquinoxaline-2-carboxylate (cas: 49679-45-0Reference of 49679-45-0).
Ethyl 3-chloroquinoxaline-2-carboxylate (cas: 49679-45-0) belongs to quinoxaline derivatives. Quinoxaline is isomeric with other naphthyridines including quinazoline, phthalazine and cinnoline. Quinoxaline-1,4-di-N-oxide derivatives have shown to improve the biological results and are endowed with anti-viral, anti-cancer, anti-bacterial, and anti-protozoal activities with application in many other therapeutic areas.Reference of 49679-45-0
Referemce:
Quinoxaline – Wikipedia,
Quinoxaline | C8H6N2 | ChemSpider