Synthesis and some reactions of quinoxalinecarboazides was written by Moustafa, O. S.. And the article was included in Journal of the Chinese Chemical Society (Taipei) in 2000.Computed Properties of C11H9ClN2O2 This article mentions the following:
Chlorination of Et (quinoxalin-2(1H)one)-3-carboxylate (I) gave Et (2-chloroquinoxaline)-3-carboxylate (II). Thionation of I by P2S5 or II by thiourea yielded the same thione product. Reaction of chloro compound II or the thio compound with hydrazine hydrate gave pyrazolylquinoxaline. The reaction of ester I with thiourea or hydrazine hydrate afforded a pyrimidoquinoxaline or carbohydrazide. The reaction of the carbohydrazide with carbon disulfide in basic medium followed by alkylation afforded oxadiazoloquinoxaline derivatives Carboazide III was produced by reaction of the pyrimidoquinoxaline with nitrous acid. Compound III on heating in an inert solvent, with or without amines, in alcs. or hydrolysis in H2O undergoes Curtius rearrangements. Reaction of IV with thiosemicarbazide gave a triazoloquinoxaline which on reaction with alkylhalides or hydrazine hydrate yielded S-alkyl or hydrazino derivatives while hydrolysis of IV gave an 3-aminoquinoxalinone which was used as an intermediate. In the experiment, the researchers used many compounds, for example, Ethyl 3-chloroquinoxaline-2-carboxylate (cas: 49679-45-0Computed Properties of C11H9ClN2O2).
Ethyl 3-chloroquinoxaline-2-carboxylate (cas: 49679-45-0) belongs to quinoxaline derivatives. Condensed heterocycles of quinoxalines have become attractive targets in synthetic and medicinal chemistry due to their significant biological activities. The parent substance of the group, quinoxaline, results when glyoxal is condensed with 1,2-diaminobenzene. Substituted derivatives arise when α-ketonic acids, α-chlorketones, α-aldehyde alcohols and α-ketone alcohols are used in place of diketones.Computed Properties of C11H9ClN2O2
Referemce:
Quinoxaline – Wikipedia,
Quinoxaline | C8H6N2 | ChemSpider