Day: January 5, 2023

Studies on potential antitubercular agents. Synthesis of 1-(2′-morpholino-3′-quinoxalinoyl)-2-benzalhydrazine and 2-aryl-3-(2′-morpholino-3′-quinoxalimido)-4-thiazolidinones was written by Fernandes, P. S.;Sonar, T. M.. And the article was included in Journal of the Indian Chemical Society in 1988.Recommanded Product: 49679-45-0 This article mentions the following:

Quinoxalinecarboxylic acid benzylidenehydrazides underwent cycloaddition-cyclocondensation with HSCH₂CO₂H to give thiazolidinones I [R¹ = Ph, thienyl, HOC₆H₆, O₂NC₆H₄, ClC₆H₄, (MeO)₃C₆H₂, HO(MeO)C₆H₃]. Some I showed antitubercular activity. In the experiment, the researchers used many compounds, for example, Ethyl 3-chloroquinoxaline-2-carboxylate (cas: 49679-45-0Recommanded Product: 49679-45-0).

Ethyl 3-chloroquinoxaline-2-carboxylate (cas: 49679-45-0) belongs to quinoxaline derivatives. Condensed heterocycles of quinoxalines have become attractive targets in synthetic and medicinal chemistry due to their significant biological activities. The antitumoral properties of quinoxaline compounds have been of interest. Recently, quinoxaline and its analogs have been investigated as the catalyst’s ligands.Recommanded Product: 49679-45-0

Referemce:
Quinoxaline – Wikipedia,
Quinoxaline | C8H6N2 | ChemSpider

Tetrabutylammonium Bromide-Catalyzed Transfer Hydrogenation of Quinoxaline with HBpin as a Hydrogen Source was written by Guo, Qi;Chen, Jingchao;Shen, Guoli;Lu, Guangfu;Yang, Xuemei;Tang, Yan;Zhu, Yuanbin;Wu, Shiyuan;Fan, Baomin. And the article was included in Journal of Organic Chemistry in 2022.Safety of 6-Chloroquinoxaline This article mentions the following:

A metal-free environmentally benign, simple, and efficient transfer hydrogenation process of quinoxaline was developed using the HBpin reagent as a hydrogen source. This reaction was compatible with a variety of quinoxalines offering the desired tetrahydroquinoxalines in moderate-to-excellent yields with Bu₄NBr as a noncorrosive and low-cost catalyst. In the experiment, the researchers used many compounds, for example, 6-Chloroquinoxaline (cas: 5448-43-1Safety of 6-Chloroquinoxaline).

6-Chloroquinoxaline (cas: 5448-43-1) belongs to quinoxaline derivatives. Condensed heterocycles of quinoxalines have become attractive targets in synthetic and medicinal chemistry due to their significant biological activities. They are well-known for application in organic light emitting devices, polymers and pharmaceutical agents. The quinoxaline-containing polymers are applicable in optical devices due to their thermal stability and low band gap.Safety of 6-Chloroquinoxaline

Referemce:
Quinoxaline – Wikipedia,
Quinoxaline | C8H6N2 | ChemSpider

Identification and optimisation of 3,3-dimethyl-azetidin-2-ones as potent and selective inhibitors of 11β-hydroxysteroid dehydrogenase type 1 (11β-HSD1) was written by McCoull, William;Augustin, Martin;Blake, Caroline;Ertan, Anne;Kilgour, Elaine;Krapp, Stephan;Moore, Jane E.;Newcombe, Nicholas J.;Packer, Martin J.;Rees, Amanda;Revill, John;Scott, James S.;Selmi, Nidhal;Gerhardt, Stefan;Ogg, Derek J.;Steinbacher, Stefan;Whittamore, Paul R. O.. And the article was included in MedChemComm in 2014.Reference of 141234-08-4 This article mentions the following:

3,3-Di-methyl-azetidin-2-ones were identified as potent and selective 11β-HSD1 inhibitors against the human and mouse forms of the enzyme. Structure guided optimization of LLE was conducted, utilizing a key polar interaction and identifying stereochem. preference for the 4S isomer. Metabolic stability was improved to afford oral exposure, providing tool compounds suitable for pre-clin. evaluation. In the experiment, the researchers used many compounds, for example, Quinoxaline-5-carbaldehyde (cas: 141234-08-4Reference of 141234-08-4).

Quinoxaline-5-carbaldehyde (cas: 141234-08-4) belongs to quinoxaline derivatives. Quinoxaline derivatives are important constituents of pharmacologically active compounds, including as well as for RNA synthesis inhibition, reactive dyes and pigments, azo dyes, flurox Cylin Dyes, Corrosion Inhibitors and Photovoltaic Polymers. Quinoxalines are used in the treatment of bacterial, cancer, and HIV infections. Moreover, varenicline, a clinical drug is used for treating nicotine addiction, also contains quinoxaline moiety.Reference of 141234-08-4

Referemce:
Quinoxaline – Wikipedia,
Quinoxaline | C8H6N2 | ChemSpider

Rationalizations among heterocyclic partition coefficients. Part 2: The azines was written by Lewis, Susan J.;Mirrlees, Margaret S.;Taylor, Peter J.. And the article was included in Quantitative Structure-Activity Relationships in 1983.Recommanded Product: 6-Chloroquinoxaline This article mentions the following:

π-Values (partition substituent constants) of 246 azines are given and discussed in terms of Δπ, the difference in π-value from that expected for C₆H₆. It is shown that Δπ is close to zero for alkyl and most halogen groups, but for polar substituents capable of H bonding it may be as high as φ1.6. Except for peri-positions, these Δπ-values may be correlated by a set of equations specific for different types of substituent position and containing terms which sep. parameterize proton-donor and -acceptor ability. The rationale behind this treatment is justified in terms of the nature of the octanol-H₂O partitioning process and the manner in which electronic effects are expected to operate, in this context and that of the individual mol. Other topics discussed include: reasons for deviations among “irregular” substituents; the special problems of peri-positions; multisubstitution; and some consequences of this anal. for other types of compound In the experiment, the researchers used many compounds, for example, 6-Chloroquinoxaline (cas: 5448-43-1Recommanded Product: 6-Chloroquinoxaline).

6-Chloroquinoxaline (cas: 5448-43-1) belongs to quinoxaline derivatives. Condensed heterocycles of quinoxalines have become attractive targets in synthetic and medicinal chemistry due to their significant biological activities. Quinoxaline and its analogues may also be formed by reduction of amino acids substituted 1,5-difluoro-2,4-dinitrobenzene (DFDNB),One study used 2-iodoxybenzoic acid (IBX) as a catalyst in the reaction of benzil with 1,2-diaminobenzene.Recommanded Product: 6-Chloroquinoxaline

Referemce:
Quinoxaline – Wikipedia,
Quinoxaline | C8H6N2 | ChemSpider

Ultraviolet absorption spectra of some simple quinoxaline derivatives was written by Perkampus, H. H.. And the article was included in Zeitschrift fuer Naturforschung in 1962.Product Details of 5448-43-1 This article mentions the following:

The UV spectra of the following quinoxaline derivatives were investigated in different solvents: 2-Me-, 2-Cl-, 2-MeO-. 2,3-di-Me-, 2,3-di-MeO-, 2,3-di-isopropoxy-, 2,3-di-Cl-, 2,3-di-Br-, 5- and 6-Me, 5- and 6-Cl, and 6,7-di-Me. Position, intensity, and assignment of the absorption bands and the fine structure of the ¹L_b band are tabulated. In the experiment, the researchers used many compounds, for example, 6-Chloroquinoxaline (cas: 5448-43-1Product Details of 5448-43-1).

6-Chloroquinoxaline (cas: 5448-43-1) belongs to quinoxaline derivatives. Condensed heterocycles of quinoxalines have become attractive targets in synthetic and medicinal chemistry due to their significant biological activities. Quinoxalines are used as dyes, pharmaceuticals, and antibiotics such as echinomycin, levomycin exhibiting antitumoral properties. Quinoxalines establish also the basis of anthelmintics and receptor antagonists.Product Details of 5448-43-1

Referemce:
Quinoxaline – Wikipedia,
Quinoxaline | C8H6N2 | ChemSpider

Efficient Microwave-Assisted Pd-Catalyzed Hydroxylation of Aryl Chlorides in the Presence of Carbonate was written by Yu, Chao-Wu;Chen, Grace S.;Huang, Chen-Wei;Chern, Ji-Wang. And the article was included in Organic Letters in 2012.Related Products of 5448-43-1 This article mentions the following:

An efficient microwave-assisted, palladium-catalyzed hydroxylation of aryl chlorides in the presence of a weak base carbonate was developed, which rapidly converts aryl and heteroaryl chlorides to phenols, and can be used when the aryl chloride is functionalized with a ketone, aldehyde, ester, nitrile, or amide. In the experiment, the researchers used many compounds, for example, 6-Chloroquinoxaline (cas: 5448-43-1Related Products of 5448-43-1).

6-Chloroquinoxaline (cas: 5448-43-1) belongs to quinoxaline derivatives. Quinoxalines have received a significant amount of attention due to their potential use in fighting various pathophysiological conditions like epilepsy, Parkinson’s, and Alzheimer’s diseases. The antitumoral properties of quinoxaline compounds have been of interest. Recently, quinoxaline and its analogs have been investigated as the catalyst’s ligands.Related Products of 5448-43-1

Referemce:
Quinoxaline – Wikipedia,
Quinoxaline | C8H6N2 | ChemSpider

B(C₆F₅)₃-promoted hydrogenations of N-heterocycles with ammonia borane was written by Ding, Fangwei;Zhang, Yiliang;Zhao, Rong;Jiang, Yanqiu;Bao, Robert Li-Yuan;Lin, Kaifeng;Shi, Lei. And the article was included in Chemical Communications (Cambridge, United Kingdom) in 2017.Electric Literature of C8H5ClN2 This article mentions the following:

A transition-metal-free method for the B(C₆F₅)₃-promoted hydrogenations of N-heterocycles using ammonia borane under mild reaction conditions was developed. The reaction afforded a broad range of hydrogenated products in moderate to good yields. The enantioselective versions for the corresponding products were also investigated via our approach, showing good feasibility. In the experiment, the researchers used many compounds, for example, 6-Chloroquinoxaline (cas: 5448-43-1Electric Literature of C8H5ClN2).

6-Chloroquinoxaline (cas: 5448-43-1) belongs to quinoxaline derivatives. Condensed heterocycles of quinoxalines have become attractive targets in synthetic and medicinal chemistry due to their significant biological activities. Quinoxaline and its analogues may also be formed by reduction of amino acids substituted 1,5-difluoro-2,4-dinitrobenzene (DFDNB),One study used 2-iodoxybenzoic acid (IBX) as a catalyst in the reaction of benzil with 1,2-diaminobenzene.Electric Literature of C8H5ClN2

Referemce:
Quinoxaline – Wikipedia,
Quinoxaline | C8H6N2 | ChemSpider

Synthesis and some reactions of quinoxalinecarboazides was written by Moustafa, O. S.. And the article was included in Journal of the Chinese Chemical Society (Taipei) in 2000.Computed Properties of C11H9ClN2O2 This article mentions the following:

Chlorination of Et (quinoxalin-2(1H)one)-3-carboxylate (I) gave Et (2-chloroquinoxaline)-3-carboxylate (II). Thionation of I by P₂S₅ or II by thiourea yielded the same thione product. Reaction of chloro compound II or the thio compound with hydrazine hydrate gave pyrazolylquinoxaline. The reaction of ester I with thiourea or hydrazine hydrate afforded a pyrimidoquinoxaline or carbohydrazide. The reaction of the carbohydrazide with carbon disulfide in basic medium followed by alkylation afforded oxadiazoloquinoxaline derivatives Carboazide III was produced by reaction of the pyrimidoquinoxaline with nitrous acid. Compound III on heating in an inert solvent, with or without amines, in alcs. or hydrolysis in H₂O undergoes Curtius rearrangements. Reaction of IV with thiosemicarbazide gave a triazoloquinoxaline which on reaction with alkylhalides or hydrazine hydrate yielded S-alkyl or hydrazino derivatives while hydrolysis of IV gave an 3-aminoquinoxalinone which was used as an intermediate. In the experiment, the researchers used many compounds, for example, Ethyl 3-chloroquinoxaline-2-carboxylate (cas: 49679-45-0Computed Properties of C11H9ClN2O2).

Ethyl 3-chloroquinoxaline-2-carboxylate (cas: 49679-45-0) belongs to quinoxaline derivatives. Condensed heterocycles of quinoxalines have become attractive targets in synthetic and medicinal chemistry due to their significant biological activities. The parent substance of the group, quinoxaline, results when glyoxal is condensed with 1,2-diaminobenzene. Substituted derivatives arise when α-ketonic acids, α-chlorketones, α-aldehyde alcohols and α-ketone alcohols are used in place of diketones.Computed Properties of C11H9ClN2O2

Referemce:
Quinoxaline – Wikipedia,
Quinoxaline | C8H6N2 | ChemSpider

The synthesis of novel, visible-wavelength, oxidizable polymerization sensitizers based on the 8-halogeno-5,12-dihydroquinoxalino[2,3-b]quinoxaline skeleton was written by Podsiadly, Radoslaw;Szymczak, Agnieszka M.;Podemska, Karolina. And the article was included in Dyes and Pigments in 2009.Quality Control of 6-Bromoquinoxaline-2,3(1H,4H)-dione This article mentions the following:

Novel dyes, based on the 8-halogeno-5,12-dihydroquinoxalino[2,3-b]quinoxaline skeleton, were synthesized and characterized using ¹H NMR spectroscopy and chem. ionization mass spectroscopy. Their electrochem. and spectral properties, such as absorption and emission spectra, quantum yield of fluorescence and quantum yield of singlet oxygen generation, were also measured. These dyes were used as oxidizable sensitizers for diphenyliodonium and N-alkoxypyridinium salts. Photoredox pairs, consisting of dyes and pyridinium or iodonium salts, were found to be effective visible-wavelength initiators of free radical or cationic polymerization, resp. The ability of each dye to act as a photoinitiator strongly depended upon its chem. structure. The heavy atoms present in the chem. structure could lead to excited triplet states within the dye, thereby facilitating electron transfer from these states. In the experiment, the researchers used many compounds, for example, 6-Bromoquinoxaline-2,3(1H,4H)-dione (cas: 1910-90-3Quality Control of 6-Bromoquinoxaline-2,3(1H,4H)-dione).

6-Bromoquinoxaline-2,3(1H,4H)-dione (cas: 1910-90-3) belongs to quinoxaline derivatives. Quinoxalines have received a significant amount of attention due to their potential use in fighting various pathophysiological conditions like epilepsy, Parkinson’s, and Alzheimer’s diseases. Quinoxalines are used in the treatment of bacterial, cancer, and HIV infections. Moreover, varenicline, a clinical drug is used for treating nicotine addiction, also contains quinoxaline moiety.Quality Control of 6-Bromoquinoxaline-2,3(1H,4H)-dione

Referemce:
Quinoxaline – Wikipedia,
Quinoxaline | C8H6N2 | ChemSpider

Ruthenium(II)-Catalyzed Regioselective 1,2-Hydrosilylation of N-Heteroarenes and Tetrel Bonding Mechanism was written by Behera, Deepak;Thiyagarajan, Subramanian;Anjalikrishna, Puthannur K.;Suresh, Cherumuttathu H.;Gunanathan, Chidambaram. And the article was included in ACS Catalysis in 2021.Category: quinoxaline This article mentions the following:

An efficient regioselective dearomatization of N-heteroarenes using a ruthenium precatalyst [Ru-(p-cymene)(PCy₃)Cl₂] 1 is achieved. Reactions were performed under mild and neat conditions. A wide variety of N-heteroarenes undergo the addition of silanes in the presence of precatalyst 1, leading to exclusive N-silyl-1,2-dihydroheteroarene products. This catalytic method displays a broad substrate scope; quinolines, isoquinolines, benzimidazoles, quinoxalines, pyrazines, pyrimidines, and pyridines undergo highly selective 1,2-dearomatization. Both electron-donating and electron-withdrawing substituents on N-heteroaromatics are well tolerated in this protocol. Mechanistic studies indicate the presence of [Ru-(p-cymene) (PCy₃)HCl] 4 in the reaction mixture, which may be the resting state of the catalyst. The complete catalytic cycle as revealed from d. functional theory (DFT) studies show that the product formation is governed by N → Si tetrel bonding. Initially, PCy₃ dissociates from 1, and further reaction of [(p-cymene)RuCl₂] 20 with silane generates the catalytically active intermediate [(p-cymene)RuHCl] 7. Heteroarene coordinates with 7, and subsequent dearomative 1,3-hydride transfer to the C2 position of the heteroaryl ligand generates an amide-ligated intermediate in which the reaction of silane occurs through a tetrel bonding and provides a selective pathway for 1,2-addition DFT studies also revealed that ruthenium-catalyzed 1,4-hydroboration of pyridines is a facile process with a free energy barrier of 3.2 kcal/mol, whereas a pathway for the 1,2-hydroboration product is not observed due to the steric effects exerted by Me groups on pinacolborane (HBpin) and p-cymene. Notably, enabled by the amine-amide inter-conversion of the coordinated heteroarene ligand, the +2 oxidation state of ruthenium intermediates remains unchanged throughout the catalytic cycle. In the experiment, the researchers used many compounds, for example, 6-Chloroquinoxaline (cas: 5448-43-1Category: quinoxaline).

6-Chloroquinoxaline (cas: 5448-43-1) belongs to quinoxaline derivatives. Quinoxaline derivatives are important constituents of pharmacologically active compounds, including antibacterial, antibiotic and antineoplastic, antifungal, anti-inflammatory and analgesic drugs. Quinoxaline-1,4-di-N-oxide derivatives have shown to improve the biological results and are endowed with anti-viral, anti-cancer, anti-bacterial, and anti-protozoal activities with application in many other therapeutic areas.Category: quinoxaline

Referemce:
Quinoxaline – Wikipedia,
Quinoxaline | C8H6N2 | ChemSpider