Proton resonance spectra of heterocycles. VIII. Substituent effects on coupling constants in bicyclic heteroaromatic compounds and the prediction of chemical shifts from coupling constants was written by Katritzky, A. R.;Takeuchi, Y.. And the article was included in Journal of the Chemical Society, Perkin Transactions 2: Physical Organic Chemistry (1972-1999) in 1972.Product Details of 5448-43-1 This article mentions the following:
Substituents affect coupling constants in bicyclic heteroaromatic compounds e.g., substituted 2,1,3-selenadiazole, benzofuroxan, quinazoline, quinoline; they increase 3Jαβ and 4Jαε, slightly decrease 4Jαγ and 5Jαδ, and have little effect on 3Jβγ. The regularities discussed allowed prediction of J in substituted systems. Ortho-substituent effects on chem. shifts relate to the corresponding 3J values in the unsubstituted compound, reflecting the dependence of both on partial bond fixation. In the experiment, the researchers used many compounds, for example, 6-Chloroquinoxaline (cas: 5448-43-1Product Details of 5448-43-1).
6-Chloroquinoxaline (cas: 5448-43-1) belongs to quinoxaline derivatives. Quinoxaline derivatives are important constituents of pharmacologically active compounds, including as well as for RNA synthesis inhibition, reactive dyes and pigments, azo dyes, flurox Cylin Dyes, Corrosion Inhibitors and Photovoltaic Polymers. The antitumoral properties of quinoxaline compounds have been of interest. Recently, quinoxaline and its analogs have been investigated as the catalyst’s ligands.Product Details of 5448-43-1
Referemce:
Quinoxaline – Wikipedia,
Quinoxaline | C8H6N2 | ChemSpider