Proton resonance spectra of heterocycles. VIII. Substituent effects on coupling constants in bicyclic heteroaromatic compounds and the prediction of chemical shifts from coupling constants was written by Katritzky, A. R.;Takeuchi, Y.. And the article was included in Journal of the Chemical Society, Perkin Transactions 2: Physical Organic Chemistry (1972-1999) in 1972.Synthetic Route of C9H8N2O This article mentions the following:
Substituents affect coupling constants in bicyclic heteroaromatic compounds e.g., substituted 2,1,3-selenadiazole, benzofuroxan, quinazoline, quinoline; they increase 3Jαβ and 4Jαε, slightly decrease 4Jαγ and 5Jαδ, and have little effect on 3Jβγ. The regularities discussed allowed prediction of J in substituted systems. Ortho-substituent effects on chem. shifts relate to the corresponding 3J values in the unsubstituted compound, reflecting the dependence of both on partial bond fixation. In the experiment, the researchers used many compounds, for example, 6-Methoxyquinoxaline (cas: 6639-82-3Synthetic Route of C9H8N2O).
6-Methoxyquinoxaline (cas: 6639-82-3) belongs to quinoxaline derivatives. Quinoxaline derivatives are important constituents of pharmacologically active compounds, including as well as for RNA synthesis inhibition, reactive dyes and pigments, azo dyes, flurox Cylin Dyes, Corrosion Inhibitors and Photovoltaic Polymers. Quinoxalines are used in the treatment of bacterial, cancer, and HIV infections. Moreover, varenicline, a clinical drug is used for treating nicotine addiction, also contains quinoxaline moiety.Synthetic Route of C9H8N2O
Referemce:
Quinoxaline – Wikipedia,
Quinoxaline | C8H6N2 | ChemSpider