Selective Functionalization of Benzo-Fused N-Heterocycles by Using In Situ Trapping Metalations was written by Nishimura, Rodolfo H. V.;Murie, Valter E.;Vessecchi, Ricardo;Clososki, Giuliano C.. And the article was included in ChemistrySelect in 2020.Computed Properties of C8H5ClN2 This article mentions the following:
Some benzo-fused N-heterocycles, e.g., I were prepared by regioselective metalation of quinoline, isoquinoline, quinoxaline and quinazoline with LiTMP in the presence of zinc chloride. Applying this strategy to synthesize an analog of the antitumor verubulin illustrated its relevance for medicinal chem. Computational calculations of the pKa values of the aromatic hydrogens helped to rationalize substrate reactivity and metalation regioselectivity by the complex-induced proximity effect concept. In the experiment, the researchers used many compounds, for example, 6-Chloroquinoxaline (cas: 5448-43-1Computed Properties of C8H5ClN2).
6-Chloroquinoxaline (cas: 5448-43-1) belongs to quinoxaline derivatives. Compounds possessing quinoxaline derivatives were bestowed with a variety of significant biological properties such as antiviral, antimalarial, anticancer, DNA intercalation, DNA duplex stabilization, and many others. Quinoxalines are used as dyes, pharmaceuticals, and antibiotics such as echinomycin, levomycin exhibiting antitumoral properties. Quinoxalines establish also the basis of anthelmintics and receptor antagonists.Computed Properties of C8H5ClN2
Referemce:
Quinoxaline – Wikipedia,
Quinoxaline | C8H6N2 | ChemSpider