Anti-depressant like activity of N-n-butyl-3-methoxyquinoxaline-2-carboxamide (6o) a 5-HT3 receptor antagonist was written by Bhatt, Shvetank;Mahesh, Radhakrishnan;Devadoss, Thangaraj;Jindal, Ankur. And the article was included in Indian Journal of Experimental Biology in 2013.Product Details of 49679-45-0 This article mentions the following:
The compound 60 (at 0.5, 1 and 2 mg/kg, i.p.) with optimum log P and pA2 value, was subjected to forced swim test (FST) and tail suspension test (TST). The compound 60 significantly reduced the duration of immobility in mice without affecting the base line locomotion in actophotometer. Moreover, 6o (2 mg/kg, i.p.), potentiated the 5-hydroxytryptophan (5-HTP)-induced head twitch responses in mice and at 1 and 2 mg/kg, i.p. antagonized the reserpine-induced hypothermia (RIH) in rats. In interaction studies with various standard drugs/ligands using FST, 6o (1 and 2 mg/kg, i.p.) potentiated the anti-depressant effect fluoxetine (5 mg/kg, i.p.) and reversed the depressant effect of parthenolide (1 mg/kg, i.p.) by reducing the duration of immobility. Furthermore, 60 (1 and 2 mg/kg, i.p.) potentiated the effect of bupropion (10 mg/kg, i.p.) in TST. The behavioral anomalies of the olfactory bulbectomized (OBX) rats were augmented by chronic 60 (1 and 2 mg/kg) treatment as observed from the modified open field test (parameters: ambulation, rearing, fecal pellet). The results suggest that compound 60 exhibited anti-depressant like effect in rodent models of depression. In the experiment, the researchers used many compounds, for example, Ethyl 3-chloroquinoxaline-2-carboxylate (cas: 49679-45-0Product Details of 49679-45-0).
Ethyl 3-chloroquinoxaline-2-carboxylate (cas: 49679-45-0) belongs to quinoxaline derivatives. Compounds possessing quinoxaline derivatives were bestowed with a variety of significant biological properties such as antiviral, antimalarial, anticancer, DNA intercalation, DNA duplex stabilization, and many others. Quinoxaline and its analogues may also be formed by reduction of amino acids substituted 1,5-difluoro-2,4-dinitrobenzene (DFDNB),One study used 2-iodoxybenzoic acid (IBX) as a catalyst in the reaction of benzil with 1,2-diaminobenzene.Product Details of 49679-45-0
Referemce:
Quinoxaline – Wikipedia,
Quinoxaline | C8H6N2 | ChemSpider