Synthesis and evaluation of in vitro antiproliferative activity of new ethyl 3-(arylethynyl)quinoxaline-2-carboxylate and pyrido[4,3-b]quinoxalin-1(2H)-one derivatives was written by Hajri, Majdi;Esteve, Marie-Anne;Khoumeri, Omar;Abderrahim, Raoudha;Terme, Thierry;Montana, Marc;Vanelle, Patrice. And the article was included in European Journal of Medicinal Chemistry in 2016.Name: Ethyl 3-chloroquinoxaline-2-carboxylate This article mentions the following:
A novel series is presented of quinoxaline derivatives, i.e. I, from which agents with antiproliferative activity have been identified. Two Et 3-(arylethynyl)quinoxaline-2-carboxylates demonstrated substantial antiproliferative activity against both human non-small cell lung carcinoma (A549) and glioblastoma (U87-MG) cell lines. Pyrido[4,3-b]quinoxalin-1(2H)-ones demonstrated poor activity against A549 and U87-MG cell lines. Three of the derivatives in Et 3-(arylethynyl)quinoxaline-2-carboxylate series demonstrated substantial antiproliferative activity. Two arylethynyl derivatives proved to be the most cytotoxic with an IC50 value of 3.3 μM for both A549 and U87-MG cell lines. In the experiment, the researchers used many compounds, for example, Ethyl 3-chloroquinoxaline-2-carboxylate (cas: 49679-45-0Name: Ethyl 3-chloroquinoxaline-2-carboxylate).
Ethyl 3-chloroquinoxaline-2-carboxylate (cas: 49679-45-0) belongs to quinoxaline derivatives. Condensed heterocycles of quinoxalines have become attractive targets in synthetic and medicinal chemistry due to their significant biological activities. They are well-known for application in organic light emitting devices, polymers and pharmaceutical agents. The quinoxaline-containing polymers are applicable in optical devices due to their thermal stability and low band gap.Name: Ethyl 3-chloroquinoxaline-2-carboxylate
Referemce:
Quinoxaline – Wikipedia,
Quinoxaline | C8H6N2 | ChemSpider