Silver-Catalyzed Three-Component Approach to Quinolines Starting from Anilines, Aldehydes, and Alcohols was written by Zhang, Xu;Liu, Wenmin;Sun, Ruixue;Xu, Xuefeng;Wang, Zhiqiang;Yan, Yanlei. And the article was included in Synlett in 2016.SDS of cas: 49679-45-0 This article mentions the following:
In the presence of AgOTf and triflic acid, anilines, aryl aldehydes and cyclohexanecarboxaldehyde, and alcs. (arylethanols, alkanols, cycloalkanols, and ethylene glycol) underwent regioselective aerobic cyclocondensation reactions in toluene at 120° to yield substituted quinolines. Kinetic isotope effects and competition reactions using preformed imines and reactions of potential intermediates in the cyclocondensation were used to suggest a mechanism for the reaction. The structure of a cyclobutaquinoline was determined by X-ray crystallog. In the experiment, the researchers used many compounds, for example, Ethyl 3-chloroquinoxaline-2-carboxylate (cas: 49679-45-0SDS of cas: 49679-45-0).
Ethyl 3-chloroquinoxaline-2-carboxylate (cas: 49679-45-0) belongs to quinoxaline derivatives. Condensed heterocycles of quinoxalines have become attractive targets in synthetic and medicinal chemistry due to their significant biological activities. The antitumoral properties of quinoxaline compounds have been of interest. Recently, quinoxaline and its analogs have been investigated as the catalyst’s ligands.SDS of cas: 49679-45-0
Referemce:
Quinoxaline – Wikipedia,
Quinoxaline | C8H6N2 | ChemSpider