Synthesis and calcium antagonist activity of dialkyl 1,4-dihydro-2,6-dimethyl-4-(nitrogenous heteroaryl)-3,5-pyridine dicarboxylates was written by Baraldi, Pier G.;Budriesi, Roberta;Cacciari, Barbara;Chiarini, Alberto;Garuti, Laura;Giovanninetti, Giuseppe;Leoni, Alberto;Roberti, Marinella. And the article was included in Collection of Czechoslovak Chemical Communications in 1992.Recommanded Product: Quinoxaline-5-carbaldehyde This article mentions the following:
A new series of 4-(nitrogenous heteroaryl)-1,4-dihydropyridine (I, R1 = e.g., indol-2-yl, quinolin-4-yl, quinoxalin-5-yl, R1 = Me or Et) antagonists were synthesized and screened for inotropic, chronotropic and calcium antagonist properties, in order to evaluate the effect on pharmacol. activity of replacement of the 4-aryl group of nifedipine-like drugs by heterocyclic moieties, such as quinoline, indole, carbazole and pyrazole. The most potent bradycardic compounds of the series elicited weak calcium antagonist activity and were stronger neg. inotropic. In the experiment, the researchers used many compounds, for example, Quinoxaline-5-carbaldehyde (cas: 141234-08-4Recommanded Product: Quinoxaline-5-carbaldehyde).
Quinoxaline-5-carbaldehyde (cas: 141234-08-4) belongs to quinoxaline derivatives. Condensed heterocycles of quinoxalines have become attractive targets in synthetic and medicinal chemistry due to their significant biological activities. The parent substance of the group, quinoxaline, results when glyoxal is condensed with 1,2-diaminobenzene. Substituted derivatives arise when α-ketonic acids, α-chlorketones, α-aldehyde alcohols and α-ketone alcohols are used in place of diketones.Recommanded Product: Quinoxaline-5-carbaldehyde
Referemce:
Quinoxaline – Wikipedia,
Quinoxaline | C8H6N2 | ChemSpider