Synthesis of 2-(Quinoxalin-2-ylamino-benzotriazolyl) Pentanedioic Derivatives as Potential Anti-Folate Agents was written by Briguglio, I.;Piras, S.;Corona, P.;Pirisi, M. A.;Burrai, L.;Boatto, G.;Gavini, E.;Rassu, G.. And the article was included in Journal of Heterocyclic Chemistry in 2016.Reference of 49679-45-0 This article mentions the following:
The chem. properties of quinoxalines and quinoxaline 1,4-dioxides with those of benzotriazole nucleus were combined with the aim to evaluate the resulting biol. properties. Two main new series, including more than 60 compounds, were prepared In the first one, the benzotriazole moiety was linked through the nitrogen atoms 1, 2, or 3, to a glutaric acid substituent to simulate a glutamic moiety. In the second series, the glutaric acid was substituted with acetic acid moiety to evaluate the effects of steric hindrance. Here, we described the multistep chem. processes to obtain all titled quinoxalines starting from com. available diamines. The classical oxidation of selected quinoxalines was unsuccessful and an independent synthetic pathway was explored to obtain new derivatives linked to the benzotriazole moieties starting from synthons bearing N-oxide functionality. In the experiment, the researchers used many compounds, for example, Ethyl 3-chloroquinoxaline-2-carboxylate (cas: 49679-45-0Reference of 49679-45-0).
Ethyl 3-chloroquinoxaline-2-carboxylate (cas: 49679-45-0) belongs to quinoxaline derivatives. Condensed heterocycles of quinoxalines have become attractive targets in synthetic and medicinal chemistry due to their significant biological activities. Modifying quinoxaline structure it is possible to obtain a wide variety of biomedical applications, namely antimicrobial activities and chronic and metabolic diseases treatment.Reference of 49679-45-0
Referemce:
Quinoxaline – Wikipedia,
Quinoxaline | C8H6N2 | ChemSpider