A novel synthesis of quinoxaline-6-carbaldehyde and its evaluation as potential antimicrobial agent was written by Pai, Nandini R.;Vishwasrao, Sandesh G.. And the article was included in Pharma Chemica in 2011.Recommanded Product: 5448-43-1 This article mentions the following:
A novel synthetic process for quinoxaline-6-carboxaldehyde (I), expected to exhibit antimicrobial activity, was presented. Compound I was evaluated for antimicrobial potency in vitro and in vivo. The min. inhibitory concentration (MIC) of the I against bacteria was determined by agar and broth dilution in vitro. The antibacterial activity was confirmed by animal experiments Toxicity and protective efficacy were tested in vivo. Compound I inhibited most of the bacterial isolates at 25-100 μg/mL, and a few were sensitive even at 10 μg/mL. It was found to be bacteriostatic against Shigella dysenteriae and bactericidal against S. aureus. When administered to mice, I protected the animals challenged with 50 MLD of Salmonella typhimurium. The drug showed inhibitory action against several pathogenic bacteria and also offered significant protection to mice against the bacterial challenge. In the experiment, the researchers used many compounds, for example, 6-Chloroquinoxaline (cas: 5448-43-1Recommanded Product: 5448-43-1).
6-Chloroquinoxaline (cas: 5448-43-1) belongs to quinoxaline derivatives. Quinoxaline derivatives are important constituents of pharmacologically active compounds, including as well as for RNA synthesis inhibition, reactive dyes and pigments, azo dyes, flurox Cylin Dyes, Corrosion Inhibitors and Photovoltaic Polymers. Quinoxalines are used in the treatment of bacterial, cancer, and HIV infections. Moreover, varenicline, a clinical drug is used for treating nicotine addiction, also contains quinoxaline moiety.Recommanded Product: 5448-43-1
Referemce:
Quinoxaline – Wikipedia,
Quinoxaline | C8H6N2 | ChemSpider