Detection of glyoxal bound to protein by gas chromatography after derivatization to quinoxaline and its application for biological sample was written by Segawa, Toshiharu;Ueno, Hitoshi;Nakamuro, Katsuhiko;Sayato, Yasuyoshi. And the article was included in Japanese Journal of Toxicology and Environmental Health in 1992.SDS of cas: 5448-43-1 This article mentions the following:
The microdetermination method for glyoxal bound to proteins in biol. samples has been developed using GC with an electron capture detector. The treatment of the glyoxal-bound protein with 4-chloro-o-phenylenediamine gave its derivative, 6-chloroquinoxaline, showing the release of glyoxal from the protein. The use of metaphosphoric acid as a precipitant of the protein was suitable. The results from Sephadex G-25 gel chromatog. coupled with this microdetermination method indicated that glyoxal binds to bovine albumin. The amounts of glyoxal bound to the albumin, fetal bovine serum, and rat liver homogenate increased with an increase of glyoxal added. In the experiment, the researchers used many compounds, for example, 6-Chloroquinoxaline (cas: 5448-43-1SDS of cas: 5448-43-1).
6-Chloroquinoxaline (cas: 5448-43-1) belongs to quinoxaline derivatives. Quinoxalines have received a significant amount of attention due to their potential use in fighting various pathophysiological conditions like epilepsy, Parkinson’s, and Alzheimer’s diseases. Modifying quinoxaline structure it is possible to obtain a wide variety of biomedical applications, namely antimicrobial activities and chronic and metabolic diseases treatment.SDS of cas: 5448-43-1
Referemce:
Quinoxaline – Wikipedia,
Quinoxaline | C8H6N2 | ChemSpider