Ag-Catalyzed Minisci C-H difluoromethylarylation of N-heteroarenes was written by Xie, Xiaojuan;Zhang, Yifang;Hao, Jian;Wan, Wen. And the article was included in Organic & Biomolecular Chemistry in 2020.Safety of 6-Methoxyquinoxaline This article mentions the following:
A mild silver-catalyzed decarboxylative difluoromethylarylation of electron-deficient N-heteroarenes e.g., I has been developed by using aryldifluoro acetic acids RC(F2)C(O)OH [R = 4-methoxyphenyl, 2H-1,3-benzodioxol-5-yl, naphthalen-1-yl, etc.] as difluoromethyl sources. This protocol provides an efficient and straightforward access to difluoromethylated heteroarenes e.g., II in moderate to excellent yields with good selectivities. Furthermore, this reaction was applicable to bioactive heteroarenes, providing a straightforward approach for the late-stage C-H difluoromethylation of pharmacophores. In the experiment, the researchers used many compounds, for example, 6-Methoxyquinoxaline (cas: 6639-82-3Safety of 6-Methoxyquinoxaline).
6-Methoxyquinoxaline (cas: 6639-82-3) belongs to quinoxaline derivatives. Condensed heterocycles of quinoxalines have become attractive targets in synthetic and medicinal chemistry due to their significant biological activities. Modifying quinoxaline structure it is possible to obtain a wide variety of biomedical applications, namely antimicrobial activities and chronic and metabolic diseases treatment.Safety of 6-Methoxyquinoxaline
Referemce:
Quinoxaline – Wikipedia,
Quinoxaline | C8H6N2 | ChemSpider