Direct Csp2-H difluoromethylation of heterocycle by K2S2O8 was written by Dai, Peng;Jiao, Jian;Wang, Qingqing;Yu, Xiang;Teng, Peng;Zhu, Yuchuan;Gu, Yu-Cheng;Zhang, Wei-Hua. And the article was included in Tetrahedron in 2021.Category: quinoxaline This article mentions the following:
A novel and efficient transition-metal-free C(sp2)-H oxidative difluoromethylation of heterocycles such as 2H-chromen-2-one, quinoxalin-2(1H)-one, quinolin-2(1H)-one, etc. has been reported. It uses stable and nontoxic NaSO2CF2H as difluoromethyl source and potassium persulfate as oxidant without the need for metal catalyst. Significantly, the reaction affords difluoromethyl heterocycles RCF2H (R = 2-oxo-2H-chromen-3-yl, 2-oxo-quinoxalin-3-yl, 2-oxo-quinolin-3-yl, etc.) in moderate to good yields with a broad substrate tolerance. In the experiment, the researchers used many compounds, for example, 2-Quinoxalinol (cas: 1196-57-2Category: quinoxaline).
2-Quinoxalinol (cas: 1196-57-2) belongs to quinoxaline derivatives. Condensed heterocycles of quinoxalines have become attractive targets in synthetic and medicinal chemistry due to their significant biological activities. Quinoxalines are used in the treatment of bacterial, cancer, and HIV infections. Moreover, varenicline, a clinical drug is used for treating nicotine addiction, also contains quinoxaline moiety.Category: quinoxaline
Referemce:
Quinoxaline – Wikipedia,
Quinoxaline | C8H6N2 | ChemSpider