Synthesis of [1,2,4]triazolo[4,3-a]quinoxaline-1,3,4-oxadiazole derivatives as potent antiproliferative agents via a hybrid pharmacophore approach was written by Kaneko, Daiki;Ninomiya, Masayuki;Yoshikawa, Rina;Ono, Yukari;Sonawane, Amol D.;Tanaka, Kaori;Nishina, Atsuyoshi;Koketsu, Mamoru. And the article was included in Bioorganic Chemistry in 2020.Electric Literature of C8H4Cl2N2 This article mentions the following:
A series of [1,2,4]triazolo[4,3-a]quinoxalines I [R1 = benzyl, anilino, styryl, etc.], EAPB0203 (N-methyl-1-(2-phenethyl)imidazo[1,2-a]quinoxalin-4-amine) incorporated with 1,3,4-oxadiazole/thiadiazoles II [X = O, S; R2 = H, Me, Cl, etc.] and imiquimod incorporated with 1,3,4-oxadiazole/thiadiazoles III [Y = O, S; R3 = Me, OH, NH2] were synthesized and assessed their antiproliferative effects against various cancer cell lines. The 1,3,4-oxadiazole derivatives demonstrated the superior effectiveness compared to imiquimod and EAPB0203. These findings highlight the excellent potential of [1,2,4]triazolo[4,3-a]quinoxaline-1,3,4-oxadiazole derivatives as anticancer agents. In the experiment, the researchers used many compounds, for example, 2,3-Dichloroquinoxaline (cas: 2213-63-0Electric Literature of C8H4Cl2N2).
2,3-Dichloroquinoxaline (cas: 2213-63-0) belongs to quinoxaline derivatives. Condensed heterocycles of quinoxalines have become attractive targets in synthetic and medicinal chemistry due to their significant biological activities. Quinoxalines are used as dyes, pharmaceuticals, and antibiotics such as echinomycin, levomycin exhibiting antitumoral properties. Quinoxalines establish also the basis of anthelmintics and receptor antagonists.Electric Literature of C8H4Cl2N2
Referemce:
Quinoxaline – Wikipedia,
Quinoxaline | C8H6N2 | ChemSpider