Development of an unexpected reaction pathway for the synthesis of 1,2,4-trisubstituted pyrrolo[1,2-a]quinoxalines through palladium-catalyzed cascade reactions was written by Keivanloo, Ali;Soozani, Atena;Bakherad, Mohammad;Mirzaee, Mahdi;Rudbari, Hadi Amiri;Bruno, Giuseppe. And the article was included in Tetrahedron in 2017.SDS of cas: 2213-63-0 This article mentions the following:
The 1,2,4-trisubstituted pyrrolo[1,2-a]quinoxalines I (R = morpholin-4-yl, pyrrolidin-1-yl, piperidin-1-yl; R1 = diethylaminyl, pyrrolidin-1-yl, piperidin-1-yl, morpholin-4-yl) are synthesized through multi-component reaction of 3-substituted 2-chloroquinoxalines II, propargyl bromide, and excess secondary amines such as morpholine, piperidine, diethylamine in the presence of a palladium-copper catalytic system. This one-pot process provides an unexpected synthesis of new trisubstituted pyrrolo[1,2-a]quinoxalines I by the introduction of two amine substituents onto the fused pyrrole rings in a single reaction procedure. The synthesized pyrrolo[1,2-a]quinoxaline derivatives I are also screened against the three bacterial strains Micrococcus luteus, Pseudomonas aeruginos, and Bacillus subtilis. According to the obtained results, compounds I (R = piperidin-1-yl, R1 = morpholin-4-yl; R = R1 = morpholin-4-yl; R = R1 = piperidin-1-yl), are active against M. luteus, and compounds I (R = piperidin-1-yl, morpholin-4-yl; R1 = piperidin-1-yl, morpholin-4-yl) are active against Ps. Aeruginos, and only compound I (R = pyrrolidin-1-yl; R1 = piperidin-1-yl) are active against all the three bacterial strains. In the experiment, the researchers used many compounds, for example, 2,3-Dichloroquinoxaline (cas: 2213-63-0SDS of cas: 2213-63-0).
2,3-Dichloroquinoxaline (cas: 2213-63-0) belongs to quinoxaline derivatives. Quinoxaline derivatives are important constituents of pharmacologically active compounds, including antibacterial, antibiotic and antineoplastic, antifungal, anti-inflammatory and analgesic drugs. Quinoxaline and its analogues may also be formed by reduction of amino acids substituted 1,5-difluoro-2,4-dinitrobenzene (DFDNB),One study used 2-iodoxybenzoic acid (IBX) as a catalyst in the reaction of benzil with 1,2-diaminobenzene.SDS of cas: 2213-63-0
Referemce:
Quinoxaline – Wikipedia,
Quinoxaline | C8H6N2 | ChemSpider