Some Aspects of the Azide-Alkyne 1,3-Dipolar Cycloaddition Reaction was written by Pokhodylo, N. T.;Tupychak, M. A.;Shyyka, O. Ya.;Obushak, M. D.. And the article was included in Russian Journal of Organic Chemistry in 2019.Safety of 3,3-Dimethyl-3,4-dihydroquinoxalin-2(1H)-one This article mentions the following:
The two most commonly used catalytic systems (Cul and CuSO4/sodium ascorbate) controlling the regioselectivity of 1,3-dipolar cycloaddition of azides to terminal alkynes were studied. Their potentialities, main disadvantages, and limitations was demonstrated by a number of examples, including reactions of low-mol.-weight azides and alkynes containing heterocyclic substituents. The possibility of using novel reagents in click reactions was discussed. In the experiment, the researchers used many compounds, for example, 3,3-Dimethyl-3,4-dihydroquinoxalin-2(1H)-one (cas: 80636-30-2Safety of 3,3-Dimethyl-3,4-dihydroquinoxalin-2(1H)-one).
3,3-Dimethyl-3,4-dihydroquinoxalin-2(1H)-one (cas: 80636-30-2) belongs to quinoxaline derivatives. Quinoxaline derivatives are important constituents of pharmacologically active compounds, including antibacterial, antibiotic and antineoplastic, antifungal, anti-inflammatory and analgesic drugs. Modifying quinoxaline structure it is possible to obtain a wide variety of biomedical applications, namely antimicrobial activities and chronic and metabolic diseases treatment.Safety of 3,3-Dimethyl-3,4-dihydroquinoxalin-2(1H)-one
Referemce:
Quinoxaline – Wikipedia,
Quinoxaline | C8H6N2 | ChemSpider