K2S2O8 Mediated Three-component Radical Cascade C3 Alkylation of Quinoxalin-2(1H)-ones with Vinylarenes and 4-Hydroxycoumarins/4-Hydroxy-6-methyl-2-pyrone was written by Sharma, Suraj;Bhuyan, Mayurakhi;Baishya, Gakul. And the article was included in ChemistrySelect in 2022.Application In Synthesis of 2-Quinoxalinol This article mentions the following:
Quinoxalin-2(1H)-ones I (R = H, Cl, NO2, Me; R1 = H, Me, 4-chlorophenyl, Bn, etc.; R2 = H, Cl, Me) undergo a three-component radical cascade C3 alkylation reaction with 4-hydroxycoumarins II (R3 = H, OMe; R4 = H, Cl, Br, Me)/4-hydroxy-6-methyl-2-pyrone by using vinyl arenes 2-R5-4-R6-C6H3CH=CH2 (R5 = H, Me; R6 = H, Cl, Br, OMe) as intermediary radical acceptors. K2S2O8 in dimethylsulfoxide (DMSO) works as the best reagent-solvent combination, which promotes the reaction under metal-, photocatalyst- and light-free conditions producing the three-component products III and IV in moderate yields. The involvement of radicals in the course of the reaction by performing several radical scavenging experiments with 2,2,6,6-tetramethylpiperidine-1-oxyl (TEMPO), di-Ph ethylene, and butylated hydroxytoluene (BHT) was also proved. In the experiment, the researchers used many compounds, for example, 2-Quinoxalinol (cas: 1196-57-2Application In Synthesis of 2-Quinoxalinol).
2-Quinoxalinol (cas: 1196-57-2) belongs to quinoxaline derivatives. Quinoxaline is isomeric with other naphthyridines including quinazoline, phthalazine and cinnoline. Quinoxaline-1,4-di-N-oxide derivatives have shown to improve the biological results and are endowed with anti-viral, anti-cancer, anti-bacterial, and anti-protozoal activities with application in many other therapeutic areas.Application In Synthesis of 2-Quinoxalinol
Referemce:
Quinoxaline – Wikipedia,
Quinoxaline | C8H6N2 | ChemSpider