Site-specific C-H chalcogenation of quinoxalin-2(1H)-ones enabled by Selectfluor reagent was written by Yuan, Jin-Wei;Zhang, Yang;Huang, Guang-Chao;Ma, Meng-Yao;Yang, Teng-Yu;Yang, Liang-Ru;Zhang, Shou-Ren;Mao, Pu;Qu, Ling-Bo. And the article was included in Organic Chemistry Frontiers in 2021.Recommanded Product: 2-Quinoxalinol This article mentions the following:
A site-specific oxidative C-H chalcogenation of quinoxalin-2(1H)-ones I (R = H, Et, n-Pr, Bn, etc.) with various diaryl diselenides/disulfides Ar(Z)2Ar (Z = S, Se; Ar = Ph, 4-fluorophenyl, 2-nitrophenyl, etc.) is presented by employing Selectfluor reagent as an oxidant. The reaction proceeds selectively at the C6 position of quinoxalin-2(1H)-ones I, and enables access to a wide array of chalcogenyl quinoxalin-2(1H)-ones II. The merits of the transformation involve excellent substrate and functional compatibility, operational simplicity, and the use of a mild oxidant. The present work offers a fundamental basis for the selective synthesis of functional quinoxalin-2(1H)-ones II from readily available feedstocks. In the experiment, the researchers used many compounds, for example, 2-Quinoxalinol (cas: 1196-57-2Recommanded Product: 2-Quinoxalinol).
2-Quinoxalinol (cas: 1196-57-2) belongs to quinoxaline derivatives. Condensed heterocycles of quinoxalines have become attractive targets in synthetic and medicinal chemistry due to their significant biological activities. Quinoxalines are used as dyes, pharmaceuticals, and antibiotics such as echinomycin, levomycin exhibiting antitumoral properties. Quinoxalines establish also the basis of anthelmintics and receptor antagonists.Recommanded Product: 2-Quinoxalinol
Referemce:
Quinoxaline – Wikipedia,
Quinoxaline | C8H6N2 | ChemSpider