The Cross-Dehydrogenative Coupling Reaction of 尾-Ketoesters with Quinoxalin-2(1H)-ones was written by Zhang, Hong-Yu;Yang, Zibing;Zhang, Huizhen;Han, Ya-Ping;Zhao, Jiquan;Zhang, Yuecheng. And the article was included in European Journal of Organic Chemistry in 2021.Formula: C8H6N2O This article mentions the following:
The cross-dehydrogenative coupling (CDC) reaction of 尾-ketoesters with quinoxalin-2(1H)-one derivatives has been successfully performed by using a readily available Cu salt as the catalyst in moderate to excellent yields under mild conditions [e.g, 1-methylquinoxalin-2(1H)-one + Et acetoacetate 鈫?I (80%, imine/enamine 鈮?1.46:1) in presence of Cu(OAc)2, TBHP and NaHCO3 in DMSO under Ar]. Owing to the characteristic of handy operation and good functional group tolerance, this protocol affords a convenient access to 伪-quinoxalinone-substituted 尾-ketoesters. Preliminary mechanistic investigations show this transformation possibly underwent an unusual ionic pathway. In the experiment, the researchers used many compounds, for example, 2-Quinoxalinol (cas: 1196-57-2Formula: C8H6N2O).
2-Quinoxalinol (cas: 1196-57-2) belongs to quinoxaline derivatives. Quinoxaline derivatives are important constituents of pharmacologically active compounds, including as well as for RNA synthesis inhibition, reactive dyes and pigments, azo dyes, flurox Cylin Dyes, Corrosion Inhibitors and Photovoltaic Polymers. The antitumoral properties of quinoxaline compounds have been of interest. Recently, quinoxaline and its analogs have been investigated as the catalyst’s ligands.Formula: C8H6N2O
Referemce:
Quinoxaline – Wikipedia,
Quinoxaline | C8H6N2 | ChemSpider