Danysz, W. et al. published their research in Current Opinion in Central & Peripheral Nervous System Investigational Drugs in 1999 | CAS: 154235-83-3

Piperidin-1-yl(quinoxalin-6-yl)methanone (cas: 154235-83-3) belongs to quinoxaline derivatives. Condensed heterocycles of quinoxalines have become attractive targets in synthetic and medicinal chemistry due to their significant biological activities. Quinoxalines are used in the treatment of bacterial, cancer, and HIV infections. Moreover, varenicline, a clinical drug is used for treating nicotine addiction, also contains quinoxaline moiety.Safety of Piperidin-1-yl(quinoxalin-6-yl)methanone

CX-516 Cortex Pharmaceuticals Inc was written by Danysz, W.. And the article was included in Current Opinion in Central & Peripheral Nervous System Investigational Drugs in 1999.Safety of Piperidin-1-yl(quinoxalin-6-yl)methanone This article mentions the following:

A review with many references CX-516, an AMPA modulator from Cortex Pharmaceuticals, is in phase I/IIa clin. trials for the symptomatic treatment of deficits in memory and cognition in Alzheimer’s disease (AD) and similar disorders. CX-516 and other members in the series are also being investigated for possible antidepressant and antipsychotic activity. Results from initial studies showed that CX-691 and CX-519, both members of the AMP Akine family, have antidepressant activities. In Jan. 1999, Cortex licensed AMP Akine technol. rights to Organon for schizophrenia and depression. Cortex entered into a Cooperative Research and Development Agreement (CRADA) with the National Institute of Neurol. Diseases and Stroke, National Institutes of Health, for the initial clin. evaluation of CX-516 in AD patients in Nov. 1996. The results of a trial of CX-516 in combination with clozapine in schizophrenia patients were presented at the International Society for Schizophrenia Research in Apr. 1999. CX-516 improved a number of aspects of cognitive function. In the experiment, the researchers used many compounds, for example, Piperidin-1-yl(quinoxalin-6-yl)methanone (cas: 154235-83-3Safety of Piperidin-1-yl(quinoxalin-6-yl)methanone).

Piperidin-1-yl(quinoxalin-6-yl)methanone (cas: 154235-83-3) belongs to quinoxaline derivatives. Condensed heterocycles of quinoxalines have become attractive targets in synthetic and medicinal chemistry due to their significant biological activities. Quinoxalines are used in the treatment of bacterial, cancer, and HIV infections. Moreover, varenicline, a clinical drug is used for treating nicotine addiction, also contains quinoxaline moiety.Safety of Piperidin-1-yl(quinoxalin-6-yl)methanone

Referemce:
Quinoxaline – Wikipedia,
Quinoxaline | C8H6N2 | ChemSpider