Quinoxalines. XXV. Synthesis and chemical properties of 2-nitroquinoxaline was written by Iijima, Chihoko. And the article was included in Yakugaku Zasshi in 1989.Quality Control of Quinoxalin-2-amine This article mentions the following:
2-Nitroquinoxaline (I) was synthesized and the chem. properties were investigated. The reaction of 2-iodoquinoxaline with AgNO2 in the presence of Bu4NF gave 44% I. I is quite reactive toward various nucleophiles and the ipso-substitution reaction of I with O-nucleophiles (OH–, CH3O–, C2H5O–, C8H5O–), S-nucleophiles (CH3S–, C6H5S–, p-CH3C6H5SO2–), N-nucleophiles (hexylamine, cyclohexylamine, piperidine, morpholine, aniline), and C-nucleophiles (CN–, di-Et malonate, malonodinitrile, benzyl cyanide, Et cyanoacetate, nitroethane, acetophenone) readily afforded the corresponding 2-substituted quinoxalines. In the experiment, the researchers used many compounds, for example, Quinoxalin-2-amine (cas: 5424-05-5Quality Control of Quinoxalin-2-amine).
Quinoxalin-2-amine (cas: 5424-05-5) belongs to quinoxaline derivatives. Compounds possessing quinoxaline derivatives were bestowed with a variety of significant biological properties such as antiviral, antimalarial, anticancer, DNA intercalation, DNA duplex stabilization, and many others. Quinoxalines are used as dyes, pharmaceuticals, and antibiotics such as echinomycin, levomycin exhibiting antitumoral properties. Quinoxalines establish also the basis of anthelmintics and receptor antagonists.Quality Control of Quinoxalin-2-amine
Referemce:
Quinoxaline – Wikipedia,
Quinoxaline | C8H6N2 | ChemSpider