Visible-light-promoted/PIFA-mediated direct C-H acylation of quinoxalin-2(1H)-ones with aldehydes was written by Ni, Hangcheng;Li, Yu;Deng, Jieyi;Shi, Xingzi;Pan, Qinhai. And the article was included in New Journal of Chemistry in 2021.Application of 1196-57-2 This article mentions the following:
A simple and mild synthesis of 3-acylated quinoxalinones I [R = Ph, 4-MeC6H4, 2-naphthyl, etc.; R1 = H, Me, allyl, etc.] had been achieved via C-H acylation reaction of quinoxalin-2(1H)-ones with aldehydes as the radical precursors under visible-light irradiation A wide variety of functional groups could be incorporated into the products by employing diverse aldehydes and quinoxalin-2(1H)-one derivatives Also, this method was applied to the modification of natural mols. and pharmaceutically relevant compounds A mechanistic study revealed that an HAT process occurred in the acylation reaction for the generation of acyl radicals, and that PIFA ([bis(trifluoroacetoxy)iodo]benzene) acted both as the photosensitizer and oxidant in this reaction. In the experiment, the researchers used many compounds, for example, 2-Quinoxalinol (cas: 1196-57-2Application of 1196-57-2).
2-Quinoxalinol (cas: 1196-57-2) belongs to quinoxaline derivatives. Quinoxaline derivatives are important constituents of pharmacologically active compounds, including as well as for RNA synthesis inhibition, reactive dyes and pigments, azo dyes, flurox Cylin Dyes, Corrosion Inhibitors and Photovoltaic Polymers. The parent substance of the group, quinoxaline, results when glyoxal is condensed with 1,2-diaminobenzene. Substituted derivatives arise when α-ketonic acids, α-chlorketones, α-aldehyde alcohols and α-ketone alcohols are used in place of diketones.Application of 1196-57-2
Referemce:
Quinoxaline – Wikipedia,
Quinoxaline | C8H6N2 | ChemSpider