A Novel Palladium-Catalyzed Synthesis of 1,2-Dihydroquinoxalines and 3,4-Dihydroquinoxalinones was written by Soederberg, Bjoern C. G.;Wallace, Jeffery M.;Tamariz, Joaquin. And the article was included in Organic Letters in 2002.Reference of 80636-30-2 This article mentions the following:
Reactions of enamines, derived from 2-nitroanilines and α-substituted aldehydes, with carbon monoxide (6 atm) in the presence of a catalytic amount of bis(dibenzylideneacetone)palladium(0) (Pd(dba)2) and 1,3-bis(diphenylphosphino)propane (dppp) afford readily separated mixtures of 1,2-dihydroquinoxalines and 3,4-dihydroquinoxalinones. Addition of a catalytic amount of 1,10-phenanthroline to the reaction mixture substantially improved the yield of products. In the experiment, the researchers used many compounds, for example, 3,3-Dimethyl-3,4-dihydroquinoxalin-2(1H)-one (cas: 80636-30-2Reference of 80636-30-2).
3,3-Dimethyl-3,4-dihydroquinoxalin-2(1H)-one (cas: 80636-30-2) belongs to quinoxaline derivatives. Condensed heterocycles of quinoxalines have become attractive targets in synthetic and medicinal chemistry due to their significant biological activities. Quinoxaline-1,4-di-N-oxide derivatives have shown to improve the biological results and are endowed with anti-viral, anti-cancer, anti-bacterial, and anti-protozoal activities with application in many other therapeutic areas.Reference of 80636-30-2
Referemce:
Quinoxaline – Wikipedia,
Quinoxaline | C8H6N2 | ChemSpider