Month: February 2023

Samaeifar, Fatemeh et al. published their research in ACS Applied Materials & Interfaces in 2022 | CAS: 105598-27-4

Dipyrazino[2,3-f:2′,3′-h]quinoxaline-2,3,6,7,10,11-hexacarbonitrile (cas: 105598-27-4) belongs to quinoxaline derivatives. Quinoxalines are important class of heterocyclic compounds, associated with wider pharmacological applications. Modifying quinoxaline structure it is possible to obtain a wide variety of biomedical applications, namely antimicrobial activities and chronic and metabolic diseases treatment.Reference of 105598-27-4

Role of Guest Materials in the Lower Stability of Solution-Coated versus Vacuum-Deposited Phosphorescent OLEDs was written by Samaeifar, Fatemeh;Aziz, Hany. And the article was included in ACS Applied Materials & Interfaces in 2022.Reference of 105598-27-4 This article mentions the following:

Utilizing different phosphorescent materials as emitter guests, this work investigates the root causes of the lower electroluminescence (EL) stability of solution-coated (SOL) organic light-emitting devices (OLEDs) relative to their vacuum-deposited (VAC) counterparts. The results show that emitter guest mols. aggregate under elec. stress, leading to the emergence of new longer-wavelength bands in the EL spectra of the devices over time. However, the intensity of these aggregation emission bands is much stronger in the case of SOL host:guest systems than that of their VAC counterparts, indicating that guest aggregation occurs much faster in the former. The results reveal that the phenomenon arises from differences in the initial morphologies and are likely associated with the use of solvents in the solution-coating process. Moreover, although excitons can drive this aggregation in the case of SOL emissive layer (EML) devices, the coexistence of excitons and polarons accelerates this phenomenon significantly. The results uncover one of the main causes of the lower stability of OLEDs made by solution coating and reveal the importance of adopting new mol. designs that make them less susceptible to aggregation for the development of SOL OLEDs with high performance. In the experiment, the researchers used many compounds, for example, Dipyrazino[2,3-f:2′,3′-h]quinoxaline-2,3,6,7,10,11-hexacarbonitrile (cas: 105598-27-4Reference of 105598-27-4).

Dipyrazino[2,3-f:2′,3′-h]quinoxaline-2,3,6,7,10,11-hexacarbonitrile (cas: 105598-27-4) belongs to quinoxaline derivatives. Quinoxalines are important class of heterocyclic compounds, associated with wider pharmacological applications. Modifying quinoxaline structure it is possible to obtain a wide variety of biomedical applications, namely antimicrobial activities and chronic and metabolic diseases treatment.Reference of 105598-27-4

Referemce:
Quinoxaline – Wikipedia,
Quinoxaline | C8H6N2 | ChemSpider

 

Peng, Ling et al. published their research in Chemical Engineering Journal (Amsterdam, Netherlands) in 2022 | CAS: 105598-27-4

Dipyrazino[2,3-f:2′,3′-h]quinoxaline-2,3,6,7,10,11-hexacarbonitrile (cas: 105598-27-4) belongs to quinoxaline derivatives. Condensed heterocycles of quinoxalines have become attractive targets in synthetic and medicinal chemistry due to their significant biological activities. Modifying quinoxaline structure it is possible to obtain a wide variety of biomedical applications, namely antimicrobial activities and chronic and metabolic diseases treatment.Synthetic Route of C18N12

High-performance non-doped near ultraviolet OLEDs with the EQE ∼ 6% and CIEy ∼ 0.03 from high-lying reverse intersystem crossing was written by Peng, Ling;Lv, Jichen;Xiao, Shu;Huo, Yumiao;Liu, Yuchao;Ma, Dongge;Ying, Shian;Yan, Shouke. And the article was included in Chemical Engineering Journal (Amsterdam, Netherlands) in 2022.Synthetic Route of C18N12 This article mentions the following:

Developing high-performance organic fluorophors with short-wavelength emission is both significant and challenging subject in the application of organic light-emitting diodes (OLEDs). A coupling hardness with distortion design concept is proposed to construct an efficient near UV (NUV) fluorophor mP2MPC with 1,4-dimethyl-2,5-diphenylbenzene as a rotatable bridge via the meta-positions linking rigid and bulky phenanthroimidazole and carbazole groups. The nondoped OLED with it as emitter not only exhibits an emission peak at 395 nm with the Commission Internationale de l’ećlairage coordinates of (0.163, 0.028), but also realizes a high forward-viewing external quantum efficiency of 6.09% due to the high-lying reverse intersystem crossing. The value still keeps ≤5.56% at 1000 cd m-2, showing a small efficiency roll-off. This is 1 of the highest efficiencies among the nondoped devices with the electroluminescence peak <400 nm. The green and red phosphorescent OLEDs with mP2MPC as host can also show excellent electroluminescence performance with the forward-viewing external quantum efficiencies over 21.5%, illustrating that mP2MPC should be a prospective material for OLEDs. In the experiment, the researchers used many compounds, for example, Dipyrazino[2,3-f:2′,3′-h]quinoxaline-2,3,6,7,10,11-hexacarbonitrile (cas: 105598-27-4Synthetic Route of C18N12).

Dipyrazino[2,3-f:2′,3′-h]quinoxaline-2,3,6,7,10,11-hexacarbonitrile (cas: 105598-27-4) belongs to quinoxaline derivatives. Condensed heterocycles of quinoxalines have become attractive targets in synthetic and medicinal chemistry due to their significant biological activities. Modifying quinoxaline structure it is possible to obtain a wide variety of biomedical applications, namely antimicrobial activities and chronic and metabolic diseases treatment.Synthetic Route of C18N12

Referemce:
Quinoxaline – Wikipedia,
Quinoxaline | C8H6N2 | ChemSpider

 

Verbeek, J. et al. published their research in Recueil des Travaux Chimiques des Pays-Bas in 1976 | CAS: 6639-82-3

6-Methoxyquinoxaline (cas: 6639-82-3) belongs to quinoxaline derivatives. Quinoxaline derivatives are important constituents of pharmacologically active compounds, including antibacterial, antibiotic and antineoplastic, antifungal, anti-inflammatory and analgesic drugs. Quinoxaline-1,4-di-N-oxide derivatives have shown to improve the biological results and are endowed with anti-viral, anti-cancer, anti-bacterial, and anti-protozoal activities with application in many other therapeutic areas.Quality Control of 6-Methoxyquinoxaline

Photochemical hydroxylation of quinoxalines was written by Verbeek, J.;Berends, W.;Van Beek, H. C. A.. And the article was included in Recueil des Travaux Chimiques des Pays-Bas in 1976.Quality Control of 6-Methoxyquinoxaline This article mentions the following:

Irradiation of quinoxaline (I) in acidic aqueous solution under anaerobic conditions gave 5-hydroxyquinoxaline (II) and the 1,4-dihydroquinoxaline radical cation (III). III was characterized by ESR spectroscopy. Under aerobic conditions II is the only irradiation product formed. The effect of substituents attached to the benzene nucleus of I is analyzed. In the experiment, the researchers used many compounds, for example, 6-Methoxyquinoxaline (cas: 6639-82-3Quality Control of 6-Methoxyquinoxaline).

6-Methoxyquinoxaline (cas: 6639-82-3) belongs to quinoxaline derivatives. Quinoxaline derivatives are important constituents of pharmacologically active compounds, including antibacterial, antibiotic and antineoplastic, antifungal, anti-inflammatory and analgesic drugs. Quinoxaline-1,4-di-N-oxide derivatives have shown to improve the biological results and are endowed with anti-viral, anti-cancer, anti-bacterial, and anti-protozoal activities with application in many other therapeutic areas.Quality Control of 6-Methoxyquinoxaline

Referemce:
Quinoxaline – Wikipedia,
Quinoxaline | C8H6N2 | ChemSpider

 

Fordham, James M. et al. published their research in Journal of Organic Chemistry in 2022 | CAS: 5448-43-1

6-Chloroquinoxaline (cas: 5448-43-1) belongs to quinoxaline derivatives. Condensed heterocycles of quinoxalines have become attractive targets in synthetic and medicinal chemistry due to their significant biological activities. Quinoxaline and its analogues may also be formed by reduction of amino acids substituted 1,5-difluoro-2,4-dinitrobenzene (DFDNB),One study used 2-iodoxybenzoic acid (IBX) as a catalyst in the reaction of benzil with 1,2-diaminobenzene.Product Details of 5448-43-1

A “Pool and Split” Approach to the Optimization of Challenging Pd-Catalyzed C-N Cross-Coupling Reactions was written by Fordham, James M.;Kollmus, Philipp;Cavegn, Monika;Schneider, Regina;Santagostino, Marco. And the article was included in Journal of Organic Chemistry in 2022.Product Details of 5448-43-1 This article mentions the following:

A screening method for the rapid identification of catalytic conditions for Pd-catalyzed C-N cross-coupling reactions was reported. The strategy evaluates mixtures of precatalysts, ligands and bases to identify productive conditions that are subsequently optimized through two deconvolution steps, which uncover the active catalyst and identify the optimal solvent and base for the catalytic system. The efficacy of this approach was demonstrated through application to a previously reported reaction, whereby both the literature conditions and addnl. solutions were retrieved. The same approach to Ni-catalyzed C-N cross-coupling was investigated in parallel but was found to be less successful due to limited activity of the evaluated reagent combinations. Finally, the utility of this method was showcased by identifying effective conditions for the Pd-catalyzed cross-coupling of complex mols., which not only revealed nonobvious solutions for the processes under evaluation, but also resulted in the discovery of new chem. reactions. In the experiment, the researchers used many compounds, for example, 6-Chloroquinoxaline (cas: 5448-43-1Product Details of 5448-43-1).

6-Chloroquinoxaline (cas: 5448-43-1) belongs to quinoxaline derivatives. Condensed heterocycles of quinoxalines have become attractive targets in synthetic and medicinal chemistry due to their significant biological activities. Quinoxaline and its analogues may also be formed by reduction of amino acids substituted 1,5-difluoro-2,4-dinitrobenzene (DFDNB),One study used 2-iodoxybenzoic acid (IBX) as a catalyst in the reaction of benzil with 1,2-diaminobenzene.Product Details of 5448-43-1

Referemce:
Quinoxaline – Wikipedia,
Quinoxaline | C8H6N2 | ChemSpider

 

Tang, Wei-Hung et al. published their research in Journal of Organometallic Chemistry in 2015 | CAS: 6639-82-3

6-Methoxyquinoxaline (cas: 6639-82-3) belongs to quinoxaline derivatives. Quinoxaline is isomeric with other naphthyridines including quinazoline, phthalazine and cinnoline. Modifying quinoxaline structure it is possible to obtain a wide variety of biomedical applications, namely antimicrobial activities and chronic and metabolic diseases treatment.Recommanded Product: 6639-82-3

Ruthenium(II) 鐣?sup>6-arene complexes containing a dinucleating ligand based on 1,8-naphthyridine was written by Tang, Wei-Hung;Liu, Yi-Hung;Peng, Shie-Ming;Liu, Shiuh-Tzung. And the article was included in Journal of Organometallic Chemistry in 2015.Recommanded Product: 6639-82-3 This article mentions the following:

Ruthenium arene half-sandwich complexes, [(鐣?sup>6-p-cymene)2Ru2(娓?L)Cl2](PF6)2 (3b, L = N,N,N’,N’-tetra-2-pyridinyl-1,8-naphthyridine-2,7-diamine) and [(鐣?sup>6-p-cymene)Ru(L’)Cl](PF6) [4, L’ = tri-2-pyridinylamine], were synthesized and characterized by spectroscopic and anal. techniques. The mol. structure of [(鐣?sup>6-p-cymene)2Ru2(娓?L)Cl2]Cl2 (3a) was further determined by single-crystal x-ray anal. The use of these ruthenium complexes as pre-catalysts for oxidative coupling of 1,2-diols/1,2-aminoalc. with o-phenylenediamines leading to quinoxalines was investigated. Complex 3b appeared to be a good catalyst for this transformation. In the experiment, the researchers used many compounds, for example, 6-Methoxyquinoxaline (cas: 6639-82-3Recommanded Product: 6639-82-3).

6-Methoxyquinoxaline (cas: 6639-82-3) belongs to quinoxaline derivatives. Quinoxaline is isomeric with other naphthyridines including quinazoline, phthalazine and cinnoline. Modifying quinoxaline structure it is possible to obtain a wide variety of biomedical applications, namely antimicrobial activities and chronic and metabolic diseases treatment.Recommanded Product: 6639-82-3

Referemce:
Quinoxaline – Wikipedia,
Quinoxaline | C8H6N2 | ChemSpider

 

Senecal, Todd D. et al. published their research in Angewandte Chemie, International Edition in 2013 | CAS: 5448-43-1

6-Chloroquinoxaline (cas: 5448-43-1) belongs to quinoxaline derivatives. Quinoxaline is isomeric with other naphthyridines including quinazoline, phthalazine and cinnoline. Quinoxalines are used as dyes, pharmaceuticals, and antibiotics such as echinomycin, levomycin exhibiting antitumoral properties. Quinoxalines establish also the basis of anthelmintics and receptor antagonists.SDS of cas: 5448-43-1

A General, Practical Palladium-Catalyzed Cyanation of (Hetero)Aryl Chlorides and Bromides was written by Senecal, Todd D.;Shu, Wei;Buchwald, Stephen L.. And the article was included in Angewandte Chemie, International Edition in 2013.SDS of cas: 5448-43-1 This article mentions the following:

The authors have disclosed a general method for the cyanation of (hetero)aryl chlorides and bromides. The authors use a palladium-catalyzed cyanation system that (1) is applicable to aryl chlorides at low to moderate catalyst loadings; (2) works well with a wide range of heterocyclic halides, including in many cases five-membered heterocycles bearing free NH groups; and (3) is complete in one hour at 閳?100鎺? The use of a nontoxic cyanide source in conjunction with wide functional-group tolerance and fast reaction times make this method particularly convenient to synthetic chemists. In the experiment, the researchers used many compounds, for example, 6-Chloroquinoxaline (cas: 5448-43-1SDS of cas: 5448-43-1).

6-Chloroquinoxaline (cas: 5448-43-1) belongs to quinoxaline derivatives. Quinoxaline is isomeric with other naphthyridines including quinazoline, phthalazine and cinnoline. Quinoxalines are used as dyes, pharmaceuticals, and antibiotics such as echinomycin, levomycin exhibiting antitumoral properties. Quinoxalines establish also the basis of anthelmintics and receptor antagonists.SDS of cas: 5448-43-1

Referemce:
Quinoxaline – Wikipedia,
Quinoxaline | C8H6N2 | ChemSpider

 

Li, Yabo et al. published their research in Tetrahedron in 2015 | CAS: 5448-43-1

6-Chloroquinoxaline (cas: 5448-43-1) belongs to quinoxaline derivatives. Compounds possessing quinoxaline derivatives were bestowed with a variety of significant biological properties such as antiviral, antimalarial, anticancer, DNA intercalation, DNA duplex stabilization, and many others. The antitumoral properties of quinoxaline compounds have been of interest. Recently, quinoxaline and its analogs have been investigated as the catalyst’s ligands.Synthetic Route of C8H5ClN2

Direct C-H arylation of heterocycles with heteroaryl chlorides using a bis(alkoxo)palladium complex was written by Li, Yabo;Wang, Jingran;Yan, Beiqi;Huang, Mengmeng;Zhu, Yu;Wu, Yusheng;Wu, Yangjie. And the article was included in Tetrahedron in 2015.Synthetic Route of C8H5ClN2 This article mentions the following:

An efficient and practical bis(alkoxo)palladium complex Cat.I catalyzed C-H arylation of heterocycles with heteroaryl chlorides has been developed. With 1 mol % of Cat.I, the direct arylation of a series of heterocycles with various heteroaryl chlorides could proceed smoothly affording desired products in moderate to excellent yields. The catalytic system allows one-pot synthesis of 2,5-diheteroaryled thiophenes via twofold direct C-H arylation. In the experiment, the researchers used many compounds, for example, 6-Chloroquinoxaline (cas: 5448-43-1Synthetic Route of C8H5ClN2).

6-Chloroquinoxaline (cas: 5448-43-1) belongs to quinoxaline derivatives. Compounds possessing quinoxaline derivatives were bestowed with a variety of significant biological properties such as antiviral, antimalarial, anticancer, DNA intercalation, DNA duplex stabilization, and many others. The antitumoral properties of quinoxaline compounds have been of interest. Recently, quinoxaline and its analogs have been investigated as the catalyst’s ligands.Synthetic Route of C8H5ClN2

Referemce:
Quinoxaline – Wikipedia,
Quinoxaline | C8H6N2 | ChemSpider

 

Dhameliya, Tejas M. et al. published their research in Journal of Organic Chemistry in 2017 | CAS: 1910-90-3

6-Bromoquinoxaline-2,3(1H,4H)-dione (cas: 1910-90-3) belongs to quinoxaline derivatives. Quinoxalines have received a significant amount of attention due to their potential use in fighting various pathophysiological conditions like epilepsy, Parkinson閳ユ獨, and Alzheimer閳ユ獨 diseases. Quinoxaline-1,4-di-N-oxide derivatives have shown to improve the biological results and are endowed with anti-viral, anti-cancer, anti-bacterial, and anti-protozoal activities with application in many other therapeutic areas.Application of 1910-90-3

Rationalization of Benzazole-2-carboxylate versus Benzazine-3-one/Benzazine-2,3-dione Selectivity Switch during Cyclocondensation of 2-Aminothiophenols/Phenols/Anilines with 1,2-Biselectrophiles in Aqueous Medium was written by Dhameliya, Tejas M.;Chourasiya, Sumit S.;Mishra, Eshan;Jadhavar, Pradeep S.;Bharatam, Prasad V.;Chakraborti, Asit K.. And the article was included in Journal of Organic Chemistry in 2017.Application of 1910-90-3 This article mentions the following:

The cyclocondensation reaction of 2-aminothiophenols with 1,2-biselectrophiles such as Et glyoxalate and di-Et oxalate in aqueous medium leads to the formation of benzothiazole-2-carboxylates via the 5-endo-trig process contrary to Baldwin’s rule. The reaction of 2-aminophenols/anilines produced the corresponding benzazine-3-ones or benzazine-2,3-diones via the 6-exo-trig process in compliance with Baldwin’s rule. The mechanistic insights of these cyclocondensation reactions using the hard-soft acid-base principle, quantum chem. calculations (d. functional theory), and orbital interaction studies rationalize the selectivity switch of benzothiazole-2-carboxylates vs. benzazine-3-ones/benzazine-2,3-diones. The presence of water facilitates these cyclocondensation reactions by lowering of the energy barrier. In the experiment, the researchers used many compounds, for example, 6-Bromoquinoxaline-2,3(1H,4H)-dione (cas: 1910-90-3Application of 1910-90-3).

6-Bromoquinoxaline-2,3(1H,4H)-dione (cas: 1910-90-3) belongs to quinoxaline derivatives. Quinoxalines have received a significant amount of attention due to their potential use in fighting various pathophysiological conditions like epilepsy, Parkinson閳ユ獨, and Alzheimer閳ユ獨 diseases. Quinoxaline-1,4-di-N-oxide derivatives have shown to improve the biological results and are endowed with anti-viral, anti-cancer, anti-bacterial, and anti-protozoal activities with application in many other therapeutic areas.Application of 1910-90-3

Referemce:
Quinoxaline – Wikipedia,
Quinoxaline | C8H6N2 | ChemSpider