Synthetic Route of 2213-63-0, A catalyst don’t appear in the overall stoichiometry of the reaction it catalyzes, but it must appear in at least one of the elementary reactions in the mechanism for the catalyzed reaction. 2213-63-0, Name is 2,3-Dichloroquinoxaline, molecular formula is C8H4Cl2N2. In a Article£¬once mentioned of 2213-63-0
Discovery of novel 2-piperidinol-3-(arylsulfonyl)quinoxalines as phosphoinositide 3-kinase alpha (PI3Kalpha) inhibitors
A series of novel 2-aliphatic cyclic amine-3-(arylsulfonyl)quinoxalines was synthesized based on the structural features of a previously identified lead, WR1. The 2-piperidinol-3-(arylsulfonyl)quinoxalines, which showed excellent antitumor activities against five human cell lines, with inhibitory activities ranging from 0.34 to 2.32 muM, proved to be a promising class of novel PI3Kalpha inhibitors. The most potent compound 10d (WR23) showed an inhibitory IC50 value of 0.025 muM against PI3Kalpha and significant pAkt suppression effect. Molecular docking analysis was performed to determine possible binding modes between PI3Kalpha and target compounds.
Balanced chemical reaction does not necessarily reveal either the individual elementary reactions by which a reaction occurs or its rate law.Synthetic Route of 2213-63-0. In my other articles, you can also check out more blogs about 2213-63-0
Reference£º
Quinoxaline – Wikipedia,
Quinoxaline | C8H6N1600 | ChemSpider