One of the major reasons for studying chemical kinetics is to use measurements of the macroscopic properties of a system, Quality Control of 2,3-Dichloroquinoxaline, such as the rate of change in the concentration of reactants or products with time.In a article, mentioned the application of 2213-63-0, Name is 2,3-Dichloroquinoxaline, molecular formula is C8H4Cl2N2
Design and synthesis of new quinoxaline derivatives as anticancer agents and apoptotic inducers
The quinoxaline scaffold is a promising platform for the discovery of active chemotherapeutic agents. Three series of quinoxaline derivatives were synthesized and biologically evaluated against three tumor cell lines (HCT116 human colon carcinoma, HepG2, liver hepatocellular carcinoma and MCF-7, human breast adenocarcinoma cell line), in addition to VEGFR-2 enzyme inhibition activity. Compounds VIId, VIIIa, VIIIc, VIIIe and XVa exhibited promising activity against the tested cell lines and weak activity against VEGFR-2. Compound VIIIc induced a significant disruption in the cell cycle profile and cell cycle arrest at the G2/M phase boundary. In further assays, the cytotoxic effect of the highly active compounds was determined using a normal Caucasian fibroblast-like fetal lung cell line (WI-38). Compound VIIIc could be considered as a lead compound that merits further optimization and development as an anti-cancer and an apoptotic inducing candidate against the HCT116 cell line.
Sometimes chemists are able to propose two or more mechanisms that are consistent with the available data. Quality Control of 2,3-Dichloroquinoxaline, If a proposed mechanism predicts the wrong experimental rate law, however, the mechanism must be incorrect.Welcome to check out more blogs about 2213-63-0, in my other articles.
Reference£º
Quinoxaline – Wikipedia,
Quinoxaline | C8H6N1315 | ChemSpider