One of the major reasons for studying chemical kinetics is to use measurements of the macroscopic properties of a system, Computed Properties of C8H7N3, such as the rate of change in the concentration of reactants or products with time.In a article, mentioned the application of 6298-37-9, Name is Quinoxalin-6-amine, molecular formula is C8H7N3
New 6-Aminoquinoxaline Derivatives with Neuroprotective Effect on Dopaminergic Neurons in Cellular and Animal Parkinson Disease Models
Parkinson’s disease (PD) is a neurodegenerative disorder of aging characterized by motor symptoms that result from the loss of midbrain dopamine neurons and the disruption of dopamine-mediated neurotransmission. There is currently no curative treatment for this disorder. To discover druggable neuroprotective compounds for dopamine neurons, we have designed and synthesized a second-generation of quinoxaline-derived molecules based on structure-activity relationship studies, which led previously to the discovery of our first neuroprotective brain penetrant hit compound MPAQ (5c). Neuroprotection assessment in PD cellular models of our newly synthesized quinoxaline-derived compounds has led to the selection of a better hit compound, PAQ (4c). Extensive in vitro characterization of 4c showed that its neuroprotective action is partially attributable to the activation of reticulum endoplasmic ryanodine receptor channels. Most interestingly, 4c was able to attenuate neurodegeneration in a mouse model of PD, making this compound an interesting drug candidate for the treatment of this disorder.
Sometimes chemists are able to propose two or more mechanisms that are consistent with the available data. Computed Properties of C8H7N3, If a proposed mechanism predicts the wrong experimental rate law, however, the mechanism must be incorrect.Welcome to check out more blogs about 6298-37-9, in my other articles.
Reference£º
Quinoxaline – Wikipedia,
Quinoxaline | C8H6N89 | ChemSpider