One of the major reasons for studying chemical kinetics is to use measurements of the macroscopic properties of a system, Safety of 2-Chloro-3-methoxyquinoxaline, such as the rate of change in the concentration of reactants or products with time.In a article, mentioned the application of 32998-25-7, Name is 2-Chloro-3-methoxyquinoxaline, molecular formula is C9H7ClN2O
Efficient synthesis of 2-phenyl-3-substituted furo/thieno[2,3-: B] quinoxalines via Sonogashira coupling reaction followed by iodocyclization and subsequent palladium-catalyzed cross-coupling reactions
In this paper, we report the successful synthesis of new 2-phenyl-3-substituted furo/thieno[2,3-b]quinoxaline derivatives from 2-chloro-3-methoxyquinoxaline and 2-chloro-3-(methylthio)quinoxaline by a three-step approach. The Sonogashira coupling reaction of the title compounds with terminal alkynes afforded 2-methoxy-3-(phenylethynyl)quinoxaline and 2-(methylthio)-3-(phenylethynyl)quinoxaline in good to excellent yields. The iodocyclization of the resulting compounds using ICl in CH2Cl2 afforded 3-iodo-2-phenylfuro[2,3-b]quinoxaline and 3-iodo-2-phenylthieno[2,3-b]quinoxaline. The subsequent palladium-catalyzed Sonogashira, Suzuki, and Heck reactions of the resulting iodo compounds led to the formation of 2,3-disubstituded furo/thieno[2,3-b]quinoxaline in high yields. All compounds were fully characterized by FT-IR, mass, 1H NMR, and 13C NMR spectral data. The synthesized quinoxaline derivatives were also screened against the two bacterial strains Escherichia coli and Micrococcus luteus.
Sometimes chemists are able to propose two or more mechanisms that are consistent with the available data. Safety of 2-Chloro-3-methoxyquinoxaline, If a proposed mechanism predicts the wrong experimental rate law, however, the mechanism must be incorrect.Welcome to check out more blogs about 32998-25-7, in my other articles.
Reference£º
Quinoxaline – Wikipedia,
Quinoxaline | C8H6N1120 | ChemSpider