1593-08-4, 2-Formylquinoxaline is a quinoxaline compound, ?involved in a variety of chemical synthesis. Rlated chemical reaction is continuously updated
EXAMPLE 67 1-[(2S,3S)-3-(N2 -Quinoxalin-2-ylmethyl-L-asparaginyl)-amino-2-hydroxy-4-phenylbutyryl]-N-t-butyl-L-prolinamide 50 mul (0.36 mmol) of triethylamine and 27 mg (0.42 mmol) of sodium cyanoborohydride were added, whilst ice-cooling, to a solution of 300 mg (0.60 mmol) of 1-[3-(L-asparaginyl)amino-2-hydroxy-4-phenylbutyryl]-N-t-butyl-L-prolinamide hydrochloride and 115 mg (0.72 mmol) of 2-formylquinoxaline in 3 ml of methanol, and the resulting mixture was stirred at room temperature for 20 hours. The progress of reaction was then stopped by adding 0.60 ml of 1N aqueous hydrochloric acid, and the solvent was removed by distillation under reduced pressure. The resulting residue was extracted with ethyl acetate. The organic extract was then washed with a 5% w/v aqueous solution of sodium hydrogencarbonate and with a saturated aqueous solution of sodium chloride, in that order, after which it was dried over anhydrous sodium sulfate. The solvent was then removed by distillation under reduced pressure, and the residue was purified by preparative thin layer chromatography, using a 16:4:1 by volume mixture of chloroform, methanol and 33% v/v aqueous acetic acid as the developing solvent, to give 76 mg of the title compound as a yellow powder, melting at 116-119 C. Elemental analysis: Calculated for C32 H41 N7 O5.1.25H2 O (molecular weight: 626.22): C, 61.37%; H, 7.00%; N, 15.66%. Found: C, 61.64%; H, 7.41%; N, 15.02%. Mass spectrum (m/z): 590, 503, 429, 327, 228, 163, 133, 70. Infrared Absorption Spectrum (KBr), numax cm-1: 3338, 1668, 1513., 1593-08-4
1593-08-4 2-Formylquinoxaline 594088, aquinoxaline compound, is more and more widely used in various.
Reference£º
Patent; Sankyo Company, Limited; US5629406; (1997); A;,
Quinoxaline – Wikipedia
Quinoxaline | C8H6N2 | ChemSpider