One of the major reasons for studying chemical kinetics is to use measurements of the macroscopic properties of a system, COA of Formula: C8H8N2O, such as the rate of change in the concentration of reactants or products with time.In a article, mentioned the application of 59564-59-9, Name is 3,4-Dihydroquinoxalin-2(1H)-one, molecular formula is C8H8N2O
Design, synthesis, molecular modeling and anti-hyperglycemic evaluation of novel quinoxaline derivatives as potential PPARgamma and SUR agonists
In our effort to develop potent anti-hyperglycemic agents with potential agonistic activities toward PPARgamma and SUR, three novel series of quinoxaline derivatives bearing sulfonylurea or sulfonylthiourea moieties with different linkers were designed and synthesized. Some of the newly synthesized compounds were evaluated in vivo for their anti-hyperglycemic activities in STZ-induced hyperglycemic rats. Compounds 15a, 15e, 19band 24aexhibited the highest anti-hyperglycemic activities with % reduction in blood glucose level of (50.58, 43.84, 45.10 and 49.62, respectively). Additionally, eight compounds revealed potent anti-hyperglycemic activities were further evaluated in vitro for their PPARgamma binding affinity and insulin-secreting ability as potential mechanisms for anti-hyperglycemic activity. Four compounds (15a, 15b, 15dand 15e) significantly bound to PPARgamma with IC50values of 0.482, 0.491, 0.350 and 0.369 muM, respectively. Moreover, Compounds 15aand 15bhave demonstrated induction of insulin-secretion with EC50values of 0.92 and 0.98 muM, respectively. Furthermore, molecular docking and pharmacophore generation techniques were carried out to investigate binding patterns and fit values of the designed compounds with PPARgamma and SUR, respectively.
Sometimes chemists are able to propose two or more mechanisms that are consistent with the available data. COA of Formula: C8H8N2O, If a proposed mechanism predicts the wrong experimental rate law, however, the mechanism must be incorrect.Welcome to check out more blogs about 59564-59-9, in my other articles.
Reference£º
Quinoxaline – Wikipedia,
Quinoxaline | C8H6N165 | ChemSpider