With the rapid development and complex challenges of chemical substances, new drug synthesis pathways are usually the most effective.1204-75-7,3-Oxo-3,4-dihydroquinoxaline-2-carboxylic acid,as a common compound, the synthetic route is as follows.
EXAMPLE 1 Preparation of 5-(3-(2,4-dimethoxyphenoxy)quinoxaline-2-carboxamido)picolinic acid (26) [00617] To 3-hydroxyquinoxaline-2-carboxylic acid (10.94 g, 57.53 mmol) was added thionyl chloride (109.1 mL, 1496 mmol) and DMF (35 drops) and the reaction was refluxed at 80 C for 17 hours. The excess thionyl chloride and Nu,Nu-dimethyl formamide were removed in vacuo to yield 3- chloroquinoxaline-2-carbonyl chloride (13 g, 99%) as a brown solid. H NMR (400 MHz, DMSO-d6) delta 8.27 – 8.18 (m, 1H), 8.18 – 8.09 (m, 1H), 8.09 – 7.93 (m, 2H) ppm., 1204-75-7
As the paragraph descriping shows that 1204-75-7 is playing an increasingly important role.
Reference£º
Patent; VERTEX PHARMACEUTICALS INCORPORATED; HADIDA-RUAH, Sara, Sabina; ANDERSON, Corey; ARUMUGAM, Vijayalaksmi; ASGIAN, Iuliana, Luci; BEAR, Brian, Richard; TERMIN, Andreas, P.; JOHNSON, James, Philip; WO2014/120815; (2014); A1;,
Quinoxaline – Wikipedia
Quinoxaline | C8H6N2 | ChemSpider