25983-13-5, Name is 6,7-Dichloroquinoxaline-2,3(1H,4H)-dione, belongs to quinoxaline compound, is a common compound. COA of Formula: C8H4Cl2N2O2In an article, once mentioned the new application about 25983-13-5.
TAK-599, a novel N-phosphono type prodrug of anti-MRSA cephalosporin T-91825: Synthesis, physicochemical and pharmacological properties
Crystalline 1 (TAK-599) is a novel N-phosphono prodrug of anti-methicillin-resistant Staphylococcus aureus (MRSA) cephalosporin 2a (T-91825) that has high affinity for penicillin-binding protein (PBP) 2? (IC50; 0.90 mug/mL) and shows potent in vitro anti-MRSA activity (MIC against MRSA N133; 1.56 mug/mL), comparable to that of vancomycin (1.56 mug/mL). Although 2a had insufficient water solubility (2.3 mg/mL) for parenteral administration, 1 showed excellent water solubility (>100 mg/mL, pH 7) as well as good chemical stability in the solid state and solution. In pharmacokinetic studies, when 1 was administered intravenously to rats and monkeys, it was rapidly converted into 2a in the blood. These results show that 1 (TAK-599) is a highly promising parenteral cephalosporin targeted for MRSA infection.
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Reference£º
Quinoxaline – Wikipedia,
Quinoxaline | C8H6N1849 | ChemSpider