With the rapid development and complex challenges of chemical substances, new drug synthesis pathways are usually the most effective.212327-10-1,7-Bromo-2-methoxyquinoxaline,as a common compound, the synthetic route is as follows.
0306] To a solution of 7-bromo-2-methoxyquinoxaline (24.1 g, 100 mmol, 1 eq.) in DMF (50 mL) and EtOH ( 250 mL ) was added NaOAc (32.8 g, 400 mmol, 4 eq.) and Pd(dppf)Cl2 (1.63 g, 2 mmol, 0.02 eq) under N2 protection. The resulting mixture was stirred at 90 C under CO (3 MPa) overnight, then cooled to rt, filtered and concentrated to afford crude ethyl 3-methoxyquinoxaline-6- carboxylate as a brown solid (23.2 g, 100%) which used in next step without further purification
212327-10-1, The synthetic route of 212327-10-1 has been constantly updated, and we look forward to future research findings.
Reference£º
Patent; NEUPHARMA, INC.; QIAN, Xiangping; ZHU, Yong-liang; WO2013/40515; (2013); A1;,
Quinoxaline – Wikipedia
Quinoxaline | C8H6N2 | ChemSpider