As an important bridge between the micro and macro material world, chemistry is one of the main methods and means for humans to understand and transform the material world., Category: quinolines-derivatives90-52-8, Name is 8-Amino-6-methoxyquinoline, SMILES is COC1=CC(N)=C2N=CC=CC2=C1, belongs to quinoxaline compound. In a article, author is Du, Kui, introduce new discover of the category.
A ratiometric fluorescent probe based on quinoline for monitoring and imaging of Leucine aminopeptidase in liver tumor cells
Leucine aminopeptidase (LAP) is known as an important potential biomarker for liver malignancy and it is urgent to develop an intuitive and effective method to monitor the activity of LAP in liver cancer. Although, numerous LAP fluorescent probes had been developed, it is still a challenge to detect LAP activity in liver cancer. Herein, combained with the DFT, we reported a novel galactose-appended hepatoma-specific ratiometric fluorescent probe (Gal-QL-Leu) based on quinoline group for imaging and tracing LAP in liver tumor cells. Probe Gal-QL-Leu demonstrated a obvious ratiometric characteristics, better selectivity, good biocompatibility and high sensitivity. Moreover, the selective imaging of LAP in HepG2, HCT116, A549 and HeLa cells had been achieved with probe Gal-QL-Leu, demonstrating good application prospect in the detection of LAP activity in liver tumor cells. (C) 2020 Published by Elsevier B.V.
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Reference:
Quinoline – Wikipedia,
,Quinoline | C9H7N – PubChem