The transformation of simple hydrocarbons into more complex and valuable products via catalytic C¨CH bond functionalisation has revolutionised modern synthetic chemistry. In an article, author is Shantharjun, Bangarigalla, once mentioned the application of 90-52-8, Category: quinolines-derivatives, Name is 8-Amino-6-methoxyquinoline, molecular formula is C10H10N2O, molecular weight is 174.1992, MDL number is MFCD00672902, category is quinoxaline. Now introduce a scientific discovery about this category.
Hydroxymethylation of quinolines via iron promoted oxidative C-H functionalization: synthesis of arsindoline-A and its derivatives
Herein, we report a mild and efficient hydroxymethylation of quinolines via an iron promoted cross-dehydrogenative coupling reaction under external acid free conditions. Various hydroxyalkyl substituted quinolines were achieved in excellent yields with well tolerated functional groups. Importantly, a few of the hydroxylmethylated quinolines were further transformed into respective aldehydes, and were successfully utilized for the synthesis of alkaloid arsindoline-A and its derivatives.
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Reference:
Quinoline – Wikipedia,
,Quinoline | C9H7N – PubChem