Chemistry is an experimental science, and the best way to enjoy it and learn about it is performing experiments. COA of Formula: C8H4Cl2N2. Introducing a new discovery about 2213-63-0, Name is 2,3-Dichloroquinoxaline
Trifluoroacetic Acid Mediated One-Pot Synthesis of Furo-Fused Quinoxalines/Pyrazines
A trifluoroacetic acid promoted step-economical one-pot approach to the synthesis of furo-fused quinoxalines/pyrazines by the reaction of 2,3-dichloroquinoxalines/pyrazines with alkynes is described. The reaction involves a selective in-situ Sonogashira coupling step and a hydroxylation followed by a metal-free 5-endo-dig cyclization. Preliminary experiments show that trifluoroacetic acid acts as a source of oxygen for the oxyarylation step, and isotopic labeling studies support the proposal that the mechanistic pathway involves activation of the alkyne by the acidic medium. Various kinds of substituents are tolerated, which should prove valuable for structural and biological investigations.
Note that a catalyst decreases the activation energy for both the forward and the reverse reactions and hence accelerates both the forward and the reverse reactions.COA of Formula: C8H4Cl2N2, you can also check out more blogs about2213-63-0
Reference£º
Quinoxaline – Wikipedia,
Quinoxaline | C8H6N1450 | ChemSpider