With the rapid development and complex challenges of chemical substances, new drug synthesis pathways are usually the most effective.1204-75-7,3-Oxo-3,4-dihydroquinoxaline-2-carboxylic acid,as a common compound, the synthetic route is as follows.
Methanol solution (70 cm3) of [RuHCl(CO)(PPh3)3] (0.2 g, 2¡Á10-4 mol)and 3-hydroxy-2-quinoxalinecarboxylic acid (0.05 g, ~2¡Á10-4 mol) wasrefluxed for 3 h. The crystals suitable for X-ray analysis were obtained byslow evaporation of the reaction mixture. Yield 82%. IR (KBr, n/cm-1):1945 (s, nRu-H), 1926 (s, nRu-CO), 1708 (s, nCOO/OH), 1641 (s, nC=N, nC=C). UV-VIS (solid state, l/nm): 475, 400, 350, 250. UV-VIS [methanol, l/nm(log e)]: 466.4 (2.52), 388.8 (3.14), 322.0 (3.70), 276.0 (4.03), 251.2(4.33), 207.2 (4.85). 1H NMR (400 MHz, CDCl3) d: 14.45 (s, OH), 13.89(s, OH), 8.68 (d, hqxc, J 8.7 Hz), 8.17 (d, hqxc, J 8.6 Hz), 7.69 (dd, 17 H,J 16.4 and 5.7 Hz), 7.64-7.10 (m, PPh3/hqxc), 6.93 (s, 4 H), -10.51 (t,HRu, J 19.1 Hz). 13C NMR (101 MHz, CDCl3) d: 173.12 (s), 158.68 (s),143.00 (s), 138.04 (s), 134.29 (s), 133.41 (dt, J 8.7 and 6.1 Hz), 132.16 (s),131.80 (dd, J 22.8 and 6.1 Hz), 131.44 (s), 128.09 (q, J 4.9 Hz), 127.76 (s),127.27 (s), 126.87 (s), 126.34 (s). 31P NMR (202 MHz, CDCl3) d: 43.69(s). Found (%): C, 65.25; H, 4.52; N, 3.27. Calc. for C46H36N2O4P2Ru (%):C, 65.48; H, 4.30; N, 3.32., 1204-75-7
The synthetic route of 1204-75-7 has been constantly updated, and we look forward to future research findings.
Reference£º
Article; Ma?ecki, Jan G.; MaronI, Anna; Kusz, Joachim; Mendeleev Communications; vol. 25; 2; (2015); p. 103 – 105;,
Quinoxaline – Wikipedia
Quinoxaline | C8H6N2 | ChemSpider