With the rapid development and complex challenges of chemical substances, new drug synthesis pathways are usually the most effective.6298-37-9,Quinoxalin-6-amine,as a common compound, the synthetic route is as follows.,6298-37-9
To a solution of 6-aminoquinoxaline (290 mg, 2 mmol) and hydroxypentadecanoic acid (518 mg, 2 mmol) in dichloromethane (40 ml) are added triethylamine (0.83 ml, 6 mmol), EDC (768 mg, 4 mmol) and HOBt (405 mg, 3 mmol). The mixture is stirred overnight at room temperature under inert atmosphere of nitrogen. The reaction is hydrolyzed, extracted with dichloromethane and then washed with a concentrated NH4Cl solution. The organic phase is dried on anhydrous MgSO4 and concentrated under reduced pressure. The residue obtained is then dissolved in DMF (10 ml), and then imidazole (136 mg, 2 mmol) and TBDMS-Cl (332 mg, 2.2 mmol) are added. The mixture is stirred overnight at room temperature under inert atmosphere of nitrogen. The reaction is hydrolyzed and then extracted with ethyl acetate, dried on anhydrous MgSO4 and concentrated under vacuum. The silylated product is purified on a silica column in a mixture of cyclohexane and ethyl acetate in a proportion of 8:2. The product is then dissolved in THF (10 ml) and TBAF (3 ml, 1 M in THF) is added. After 5 minutes the reaction is hydrolyzed and extracted with ethyl acetate. The organic phase is dried on anhydrous MgSO4 and concentrated under vacuum. The product is obtained with a total yield of 38% on three steps.
As the paragraph descriping shows that 6298-37-9 is playing an increasingly important role.
Reference£º
Patent; CENTRE NATIONAL DE LA RECHERCHE SCIENTIFIQUE(CNRS); US2011/118270; (2011); A1;,
Quinoxaline – Wikipedia
Quinoxaline | C8H6N2 | ChemSpider