With the rapid development and complex challenges of chemical substances, new drug synthesis pathways are usually the most effective.1910-90-3,6-Bromoquinoxaline-2,3(1H,4H)-dione,as a common compound, the synthetic route is as follows.
EXAMPLE 1 6-Bromo-2,3-dihydroxy-7-nitroquinoxaline To a solution of 0.5 g (2.1 mmol) of 6-bromo-2,3-dihydroxy quinoxaline in 5 ml of concentrated sulfuric acid is added at 0 C. 210 mg (2.1 mmol) KNO3. The solution is stirred at 0 C. for 30 min. and at 24 C. for 3 h. The reaction mixture is poured into ice-water giving 5 g precipitate. The crude product is dissolved in 30 ml of hot 2N NaOH. 4N HCl is added ajusting pH to 2 giving 0.4 g (67%) of 6-bromo-2,3-dihydroxy-7-nitro-quinoxaline, m.p. >300 C. NMR: two singlets (ppm 7.3 and 7.7 downfield from TMS).
1910-90-3, The synthetic route of 1910-90-3 has been constantly updated, and we look forward to future research findings.
Reference£º
Patent; A/S Ferrosan; US4812458; (1989); A;,
Quinoxaline – Wikipedia
Quinoxaline | C8H6N2 | ChemSpider