With the rapid development and complex challenges of chemical substances, new drug synthesis pathways are usually the most effective.32601-86-8,2-Chloro-3-methylquinoxaline,as a common compound, the synthetic route is as follows.
A mixture of 2-chloro-3-methylquinoxaline (100 mg, 0.56 mmol), 2-chlorophenol (144 mg, 1.12 mmol) and potassium carbonate (929 mg, 6.72 mmol) in DMSO (5.6 mL) was heated at 120C in a sealed tube for 18 h. The reaction mixture was partitioned between EtOAc (60 mL) and water (60 mL). The organic layer was separated and the aqueous layer was back-extracted with 10% propan-2-ol in chloroform (2 x 60 mL). The combined organic layers were dried (Na2S04) and concentrated in vacuo. The residue was purified by flash column chromatography (Si02, 0-100% EtO Ac/heptane, followed by 1-100%) MeOH/EtOAc), then repurified by preparative HPLC, yielding the title compound (37.5 mg, 24%) as an off-white solid. deltaEta (500 MHz, DMSO-d6) 8.03-7.99 (m, IH), 7.73-7.58 (m, 4H), 7.56-7.45 (m, 2H), 7.44-7.35 (m, IH), 2.80 (s, 3H). LCMS (ES+) 271.0/273.0 (M+H)+, RT 1.69 minutes., 32601-86-8
The synthetic route of 32601-86-8 has been constantly updated, and we look forward to future research findings.
Reference£º
Patent; UCB BIOPHARMA SPRL; ALEXANDER, Rikki Peter; FOULKES, Gregory; HUTCHINGS, Martin Clive; JACKSON, Victoria Elizabeth; KROEPLIEN, Boris; REUBERSON, James Thomas; ROOK, Sarah Margaret; ZHU, Zhaoning; WO2015/86523; (2015); A1;,
Quinoxaline – Wikipedia
Quinoxaline | C8H6N2 | ChemSpider