55687-05-3,With the rapid development and complex challenges of chemical substances, new drug synthesis pathways are usually the most effective.55687-05-3,2,5-Dichloroquinoxaline,as a common compound, the synthetic route is as follows.
Step 4: 2,5-dichloroquinoxaline (90 mg, 0.452 mmol), 3-bromophenol (86 mg, 0.497 mmol) and potassium carbonate (82 mg, 0.542 mmol) were heated to 90 C. in anhydrous acetonitrile (3 mL) for 18 hours. The reaction was allowed to cool to room temperature and transferred to a separatory funnel with ethyl acetate and washed with water, 1N aqueous sodium hydroxide solution, brine, dried (MgSO4), filtered, and the solvent removed in vacuo, to give an off white solid. This material was adsorbed onto silica and purified by column chromatography, eluding with a gradient of 0-25% ethyl acetate in hexane to afford 2-(3-bromophenoxy)-5-chloroquinoxaline as a white solid (130 mg, 86% Yield); MS (ESI) m/z 333.95087; HRMS: calcd for C14H8BrClN2O+H+, 334.9581. found (ESI, [M+H]+ Obs’d), 334.9583.
The synthetic route of 55687-05-3 has been constantly updated, and we look forward to future research findings.
Reference£º
Patent; Wyeth; US2010/120778; (2010); A1;,
Quinoxaline – Wikipedia
Quinoxaline | C8H6N2 | ChemSpider