With the rapid development and complex challenges of chemical substances, new drug synthesis pathways are usually the most effective.55687-02-0,6-Bromo-2-chloroquinoxaline,as a common compound, the synthetic route is as follows.
55687-02-0, Methyl (S)-3-methyl-1-oxo-1-((S)-2-(6-(6-(4,4,5,5-tetramethyl-1,3,2-dioxaborolan-2-yl)quinoxalin-2-yl)-1H-benzo[d]imidazol-2-yl)pyrrolidin-1-yl)butan-2-ylcarbamate In a 10 mL seal tube, methyl (S)-3-methyl-1-oxo-1-((S)-2-(5-(4,4,5,5-tetramethyl-1,3,2-dioxaborolan-2-yl)-1H-benzo[d]imidazol-2-yl)pyrrolidin-1-yl)butan-2-ylcarbamate (100 mg, 213 mmol, Eq: 1.00), 6-bromo-2-chloroquinoxaline (51.8 mg, 213 mumol, Eq: 1.00) and cesium carbonate (139 mg, 425 mumol, Eq: 2.0) were combined with 1,4 dioxane (2.00 ml) and water (0.4 ml) to give a light brown solution. It was degassed for 10 min and tetrakis(triphenylphosphine)palladium (0) (24.6 mg, 21.3 mumol, Eq: 0.1) was added. The reaction mixture was heated to 80 C. and stirred for 16 h. It was diluted with EtOAc (6 ml), filtered through celite, concentrated in vacuo and purified on a silica gel column (CH2Cl2, 2%, 3%, 5%, 8%, 10% MeOH/CH2Cl2) to afford methyl (S)-1-((S)-2-(5-(6-bromoquinoxalin-2-yl)-1H-benzo[d]imidazol-2-yl)pyrrolidin-1-yl)-3-methyl-1-oxobutan-2-ylcarbamate as a solid (100 mg, 85.3%). ESI-LRMS m/e calcd for C26H27BrN6O3 [M+] 551, found 552 [M+H+].
The synthetic route of 55687-02-0 has been constantly updated, and we look forward to future research findings.
Reference£º
Patent; Alam, Muzaffar; Berthel, Steven Joseph; Brinkman, John A.; Hawley, Ronald Charles; Li, Hongju; Palmer, Wylie Solang; Pietranico-Cole, Sherrie; Sarabu, Ramakanth; Smith, Mark; So, Sung-Sau; Yi, Lin; Zhai, Yansheng; Zhang, Qiang; Zhao, Shu-Hai; US2012/230951; (2012); A1;,
Quinoxaline – Wikipedia
Quinoxaline | C8H6N2 | ChemSpider